UniProt Accession

 PKHF1_MOUSE; Q3TB82; Q99M16 

Genbank Protein ID

 AK143976; AK157990; AK170283; AK171398; BC002120 

Genbank Nucleotide ID

 BAE25641.1; BAE34303.1; BAE41685.1; BAE42432.1; AAH02120.1 

Protein Name

 Pleckstrin homology domain-containing family F member 1 

Protein Synonyms/Alias

 PH domain-containing family F member 1; Lysosome-associated apoptosis-inducing protein containing PH and FYVE domains 

Gene Name

 Plekhf1 

Gene Synonyms/Alias

 Lapf 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
44	LGEGVLTKECRKKAK	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase- independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8 (By similarity). 

Sequence Annotation

 DOMAIN 35 131 PH.
 ZN_FING 152 212 FYVE-type.  

Keyword

 Apoptosis; Complete proteome; Cytoplasm; Lysosome; Metal-binding; Nucleus; Reference proteome; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 279 AA 

Protein Sequence

Gene Ontology

 GO:0005768; C:endosome; IEA:Compara.
 GO:0005764; C:lysosome; IDA:MGI.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0032266; F:phosphatidylinositol-3-phosphate binding; IEA:Compara.
 GO:0070273; F:phosphatidylinositol-4-phosphate binding; IEA:Compara.
 GO:0010314; F:phosphatidylinositol-5-phosphate binding; IEA:Compara.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0007032; P:endosome organization; IEA:Compara.
 GO:0006917; P:induction of apoptosis; IDA:MGI.
 GO:0010508; P:positive regulation of autophagy; IEA:Compara.
 GO:0072659; P:protein localization to plasma membrane; IEA:Compara.
 GO:0046902; P:regulation of mitochondrial membrane permeability; ISA:MGI.
 GO:0016050; P:vesicle organization; IEA:Compara. 

Interpro

 IPR011993; PH_like_dom.
 IPR001849; Pleckstrin_homology.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 

Pfam

 PF01363; FYVE
 PF00169; PH 

SMART

 SM00064; FYVE
 SM00233; PH 

PROSITE

 PS50003; PH_DOMAIN
 PS50178; ZF_FYVE 

PRINTS