CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-010061
UniProt Accession
Genbank Protein ID
 U00089 
Genbank Nucleotide ID
Protein Name
 Ribonuclease 3 
Protein Synonyms/Alias
 Ribonuclease III; RNase III 
Gene Name
 rnc 
Gene Synonyms/Alias
 MPN_545; MP297 
Created Date
 July 27, 2013 
Organism
 Mycoplasma pneumoniae (strain ATCC 29342 / M129) 
NCBI Taxa ID
 272634 
Lysine Modification
Position
Peptide
Type
References
17KPKVIDEKFVAFFKSacetylation[1]
Reference
 [1] Cross-talk between phosphorylation and lysine acetylation in a genome-reduced bacterium.
 van Noort V, Seebacher J, Bader S, Mohammed S, Vonkova I, Betts MJ, Kühner S, Kumar R, Maier T, O'Flaherty M, Rybin V, Schmeisky A, Yus E, Stülke J, Serrano L, Russell RB, Heck AJ, Bork P, Gavin AC.
 Mol Syst Biol. 2012 Feb 28;8:571. [PMID: 22373819
Functional Description
 Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Also processes some mRNAs, and tRNAs when they are encoded in the rRNA operon (By similarity). 
Sequence Annotation
 DOMAIN 18 141 RNase III.
 ACT_SITE 63 63 Potential.
 ACT_SITE 130 130 By similarity.
 METAL 59 59 Magnesium (By similarity).
 METAL 127 127 Magnesium (By similarity).
 METAL 130 130 Magnesium (By similarity).  
Keyword
 Complete proteome; Cytoplasm; Endonuclease; Hydrolase; Magnesium; Metal-binding; mRNA processing; Nuclease; Reference proteome; rRNA processing; tRNA processing. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 282 AA 
Protein Sequence
MKNKKDKTQK PKVIDEKFVA FFKSLNIEPQ NWQFYEDAFV HSSYVNENED ARASYDRLEF 60
LGDALIDFIV AKKLFELYPN YNEGMLTRTK IEIVKGENLN RIGKELNFGN FIKLGKGMPY 120
TETLFGDVLE ALVAAIYEDL GIEKANQFVE EHIFKKTYSE ILKYNFFSLF QEQKLPEPRV 180
RVSLTSNNLV LSIIELNGDI IWSQAVPNSK HYDDKSVLEH NAMSAFTQFL KSGKGINFFS 240
DIKNKLDSQK PMRALTVRPK KINWKARKPK LKALKNKVKA DS 282 
Gene Ontology
 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0004525; F:ribonuclease III activity; IEA:HAMAP.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0006397; P:mRNA processing; IEA:HAMAP.
 GO:0090305; P:nucleic acid phosphodiester bond hydrolysis; IEA:GOC.
 GO:0016075; P:rRNA catabolic process; IEA:InterPro.
 GO:0006364; P:rRNA processing; IEA:HAMAP.
 GO:0008033; P:tRNA processing; IEA:UniProtKB-KW. 
Interpro
 IPR011907; RNase_III.
 IPR000999; RNase_III_dom. 
Pfam
 PF00636; Ribonuclease_3 
SMART
 SM00535; RIBOc 
PROSITE
 PS00517; RNASE_3_1
 PS50142; RNASE_3_2 
PRINTS