UniProt Accession

 PFD2_MOUSE; O70591; Q8R0H2 

Genbank Protein ID

 Y17393; BC026839; BC049606 

Genbank Nucleotide ID

 CAA76760.1; AAH26839.1; AAH49606.1 

Protein Name

 Prefoldin subunit 2 

Protein Synonyms/Alias

  

Gene Name

 Pfdn2 

Gene Synonyms/Alias

 Pfd2 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
18	SGGSGAGKGAVSAEQ	ubiquitination	[1]
94	LPALEGNKEQIQKII	ubiquitination	[1]
99	GNKEQIQKIIETLSQ	ubiquitination	[1]
113	QQLQAKGKELNEFRE	ubiquitination	[1]
132	RLMGEDEKPAAKENS	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. 

Sequence Annotation

  

Keyword

 Chaperone; Complete proteome; Cytoplasm; Mitochondrion; Nucleus; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 154 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; TAS:MGI.
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0016272; C:prefoldin complex; IEA:InterPro.
 GO:0006457; P:protein folding; IDA:MGI. 

Interpro

 IPR027235; PFD2.
 IPR002777; PFD_beta-like.
 IPR009053; Prefoldin. 

Pfam

 PF01920; Prefoldin_2 

SMART

  

PROSITE

  

PRINTS