CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-043919
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 AF4/FMR2 family member 4 
Protein Synonyms/Alias
  
Gene Name
 AFF4 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
13GNSMTELKPSSKAHLubiquitination[1]
22SSKAHLTKLKIPSQPubiquitination[2]
24KAHLTKLKIPSQPLDubiquitination[2, 3]
46SCVDEILKESQQSNFubiquitination[2]
59NFGTGEQKRYNPSKTubiquitination[1, 3]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [2] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [3] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 171 AA 
Protein Sequence
XSQSHGNSMT ELKPSSKAHL TKLKIPSQPL DASASGDVSC VDEILKESQQ SNFGTGEQKR 60
YNPSKTSNGH QSKSMLKDDL KLSSSEDSDG EQDCDKTMPR STPGSNSEPS HHNSEGADNS 120
RDDSSSHSGS ESSSGSDSES ESSSSDSEAN EPSQSASPEP EPPPTNKWQL D 171 
Gene Ontology
  
Interpro
 IPR007797; TF_AF4/FMR2. 
Pfam
 PF05110; AF-4 
SMART
  
PROSITE
  
PRINTS