| Tag | Content |
|---|
| CPLM ID | CPLM-021220 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Histone deacetylase complex subunit SAP130 |
Protein Synonyms/Alias | 130 kDa Sin3-associated polypeptide; Sin3-associated polypeptide p130 |
Gene Name | SAP130 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 972 | LQEIANQKGVSCRAQ | ubiquitination | [1] |
|
Reference | [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments. Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA. Mol Cell Proteomics. 2013 Mar;12(3):825-31. [ PMID: 23266961] |
Functional Description | Acts as a transcriptional repressor. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. |
Sequence Annotation | REGION 836 1047 Interactions with SIN3A and HDAC1.
MOD_RES 355 355 Phosphothreonine.
MOD_RES 442 442 Phosphoserine.
MOD_RES 855 855 Phosphoserine.
MOD_RES 856 856 Phosphothreonine.
MOD_RES 875 875 Phosphoserine. |
Keyword | Acetylation; Alternative splicing; Complete proteome; Nucleus; Phosphoprotein; Reference proteome; Repressor; Transcription; Transcription regulation; Ubl conjugation. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1048 AA |
Protein Sequence | MGPPRHPQAG EIEAGGAGGG RRLQVEMSSQ QFPRLGAPST GLSQAPSQIA NSGSAGLINP 60
AATVNDESGR DSEVSAREHM SSSSSLQSRE EKQEPVVVRP YPQVQMLSTH HAVASATPVA 120
VTAPPAHLTP AVPLSFSEGL MKPPPKPTMP SRPIAPAPPS TLSLPPKVPG QVTVTMESSI 180
PQASAIPVAT ISGQQGHPSN LHHIMTTNVQ MSIIRSNAPG PPLHIGASHL PRGAAAAAVM 240
SSSKVTTVLR PTSQLPNAAT AQPAVQHIIH QPIQSRPPVT TSNAIPPAVV ATVSATRAQS 300
PVITTTAAHA TDSALSRPTL SIQHPPSAAI SIQRPAQSRD VTTRITLPSH PALGTPKQQL 360
HTMAQKTIFS TGTPVAAATV APILATNTIP SATTAGSVSH TQAPTSTIVT MTVPSHSSHA 420
TAVTTSNIPV AKVVPQQITH TSPRIQPDYP AERSSLIPIS GHRASPNPVA METRSDNRPS 480
VPVQFQYFLP TYPPSAYPLA AHTYTPITSS VSTIRQYPVS AQAPNSAITA QTGVGVASTV 540
HLNPMQLMTV DASHARHIQG IQPAPISTQG IQPAPIGTPG IQPAPLGTQG IHSATPINTQ 600
GLQPAPMGTQ QPQPEGKTSA VVLADGATIV ANPISNPFSA APAATTVVQT HSQSASTNAP 660
AQGSSPRPSI LRKKPATDGM AVRKTLIPPQ PPDVASPRVE SSMRSTSGSP RPAGAKPKSE 720
IHVSMATPVT VSMETVSNQN NDQPTIAVPP TAQQPPPTIP TMIAAASPPS QPAVALSTIP 780
GAVPITPPIT TIAAAPPPSV TVGGSLSSVL GPPVPEIKVK EEVEPMDIMR PVSAVPPLAT 840
NTVSPSLALL ANNLSMPTSD LPPGASPRKK PRKQQHVIST EEGDMMETNS TDDEKSTAKS 900
LLVKAEKRKS PPKEYIDEEG VRYVPVRPRP PITLLRHYRN PWKAAYHHFQ RYSDVRVKEE 960
KKAMLQEIAN QKGVSCRAQG WKVHLCAAQL LQLTNLEHDV YERLTNLQEG IIPKKKAATD 1020
DDLHRINELI QGNMQRCKLV MDQISEARDS MLKVLDHKDR VLKLLNKNGT VKKVSKLKRK 1080
EKV 1083 |
Gene Ontology | GO:0030914; C:STAGA complex; IDA:UniProtKB. GO:0003713; F:transcription coactivator activity; IDA:UniProtKB. GO:0043966; P:histone H3 acetylation; IDA:UniProtKB. GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:BHF-UCL. GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |