CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030673
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Xylulose kinase 
Protein Synonyms/Alias
 cDNA FLJ53504, highly similar to Xylulose kinase (EC 2.7.1.17) 
Gene Name
 XYLB 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
41FTGNQIAKIYQQNPEubiquitination[1, 2, 3, 4, 5]
282IEGQFMAKRIHAEGLubiquitination[4]
298YRVMSKTKILATGGAubiquitination[4]
357VPFSEVVKLAPNPRLubiquitination[4]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Global identification of modular cullin-RING ligase substrates.
 Emanuele MJ, Elia AE, Xu Q, Thoma CR, Izhar L, Leng Y, Guo A, Chen YN, Rush J, Hsu PW, Yen HC, Elledge SJ.
 Cell. 2011 Oct 14;147(2):459-74. [PMID: 21963094]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Kinase; Reference proteome; Transferase. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 399 AA 
Protein Sequence
MDSSTTAQCR QLEAAVGGAQ ALSCLTGSRA YERFTGNQIA KIYQQNPEAY SHTERISLVS 60
SFAASLFLGS YSPIDYSDGS GMNLLQIQDK VWSQACLGAC APHLEEKLSP PVPSCSVVGA 120
ISSYYVQRYG FPPGCKVVAF TGDNPASLAG MRLEEGDIAV SLGTSDTLFL WLQEPMPALE 180
GHIFCNPVDS QHYMALLCFK NGSLMREKIR NESVSRSWSD FSKALQSTEM GNGGNLGFYF 240
DVMEITPEII GRHRFNTENH KVAAFPGDVE VRALIEGQFM AKRIHAEGLG YRVMSKTKIL 300
ATGGASHNRE ILQVLADVFD APVYVIDTAN SACVGSAYRA FHGLAGGTDV PFSEVVKLAP 360
NPRLAATPSP GASQVYEALL PQYAKLEQRI LSQTRGPPE 399 
Gene Ontology
 GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
 GO:0016773; F:phosphotransferase activity, alcohol group as acceptor; IEA:InterPro.
 GO:0005975; P:carbohydrate metabolic process; IEA:InterPro. 
Interpro
 IPR018485; Carb_kinase_FGGY_C.
 IPR018484; Carb_kinase_FGGY_N. 
Pfam
 PF02782; FGGY_C
 PF00370; FGGY_N 
SMART
  
PROSITE
  
PRINTS