CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-013191
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Zinc finger protein 260 
Protein Synonyms/Alias
 Zfp-260 
Gene Name
 ZNF260 
Gene Synonyms/Alias
 ZFP260 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
90YKCNKCGKAFSQKENacetylation[1]
204CGKAFSQKENLIIHQubiquitination[2, 3]
232CGKAFIQKSSLIRHQubiquitination[4]
330VRIHTGDKPYECKVCubiquitination[4]
Reference
 [1] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961] 
Functional Description
 Transcription factor that acts as a cardiac regulator and an effector of alpha1-adrenergic signaling. Binds to PE response elements (PERE) present in the promoter of genes such as ANF/NPPA and acts as a direct transcriptional activator of NPPA. Also acts as a cofactor with GATA4, a key cardiac regulator (By similarity). 
Sequence Annotation
 ZN_FING 27 49 C2H2-type 1.
 ZN_FING 55 77 C2H2-type 2.
 ZN_FING 83 105 C2H2-type 3.
 ZN_FING 136 158 C2H2-type 4.
 ZN_FING 164 186 C2H2-type 5.
 ZN_FING 192 214 C2H2-type 6.
 ZN_FING 220 242 C2H2-type 7.
 ZN_FING 248 270 C2H2-type 8.
 ZN_FING 276 298 C2H2-type 9.
 ZN_FING 304 326 C2H2-type 10.
 ZN_FING 332 354 C2H2-type 11.
 ZN_FING 360 382 C2H2-type 12.
 ZN_FING 388 412 C2H2-type 13.  
Keyword
 Activator; Complete proteome; Developmental protein; DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat; Transcription; Transcription regulation; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 412 AA 
Protein Sequence
MIGMLESLQH ESDLLQHDQI HTGEKPYECN ECRKTFSLKQ NLVEHKKMHT GEKSHECTEC 60
GKVCSRVSSL TLHLRSHTGK KAYKCNKCGK AFSQKENFLS HQKHHTGEKP YECEKVSIQM 120
PTIIRHQKNH TGTKPYACKE CGKAFNGKAY LTEHEKIHTG EKPFECNQCG RAFSQKQYLI 180
KHQNIHTGKK PFKCSECGKA FSQKENLIIH QRIHTGEKPY ECKGCGKAFI QKSSLIRHQR 240
SHTGEKPYTC KECGKAFSGK SNLTEHEKIH IGEKPYKCNE CGTIFRQKQY LIKHHNIHTG 300
EKPYECNKCG KAFSRITSLI VHVRIHTGDK PYECKVCGKA FCQSSSLTVH MRSHTGEKPY 360
GCNECGKAFS QFSTLALHMR IHTGEKPYQC SECGKAFSQK SHHIRHQRIH TH 412 
Gene Ontology
 GO:0005737; C:cytoplasm; IDA:HPA.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0007275; P:multicellular organismal development; IEA:UniProtKB-KW.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 
Pfam
  
SMART
 SM00355; ZnF_C2H2 
PROSITE
 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 
PRINTS