CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017046
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 SURP and G-patch domain-containing protein 2 
Protein Synonyms/Alias
 Arginine/serine-rich-splicing factor 14; Splicing factor, arginine/serine-rich 14 
Gene Name
 SUGP2 
Gene Synonyms/Alias
 KIAA0365; SFRS14 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
18FDAVLQEKAKRYHMDubiquitination[1]
137HFRSQDWKFALRGSWubiquitination[1, 2, 3]
181GSSRLIEKECLEKESubiquitination[1]
186IEKECLEKESRDYDVubiquitination[1]
228QEGSLLGKGETQGLLubiquitination[1]
297DIQFPIQKIPLGLDLubiquitination[1, 4]
305IPLGLDLKNLRLPRRubiquitination[1, 2, 3]
321MSFDIIDKSDVFSRFubiquitination[1]
409FLNMLLDKGAVKTKNubiquitination[1]
423NCFFEIIKPFDKYIMubiquitination[1]
427EIIKPFDKYIMRLQDubiquitination[2, 3]
478TTNSLCRKSLALLGQubiquitination[1]
532REYIDHLKAWLVSSGubiquitination[1]
546GCPLQVKKAEPEPMRubiquitination[1]
595GTIDQLVKRVIEGSLubiquitination[2, 3]
650NLRGADQKPTSADCAubiquitination[1]
673AVRNLKKKLLPWQRRubiquitination[2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 May play a role in mRNA splicing (Potential). 
Sequence Annotation
 REPEAT 590 633 SURP motif 1.
 REPEAT 787 830 SURP motif 2.
 DOMAIN 1011 1057 G-patch.
 MOTIF 995 1000 Nuclear localization signal (Potential).
 MOD_RES 7 7 Phosphothreonine.
 MOD_RES 275 275 Phosphothreonine.
 MOD_RES 277 277 Phosphoserine.  
Keyword
 3D-structure; Alternative splicing; Complete proteome; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1082 AA 
Protein Sequence
MAARRITQET FDAVLQEKAK RYHMDASGEA VSETLQFKAQ DLLRAVPRSR AEMYDDVHSD 60
GRYSLSGSVA HSRDAGREGL RSDVFPGPSF RSSNPSISDD SYFRKECGRD LEFSHSDSRD 120
QVIGHRKLGH FRSQDWKFAL RGSWEQDFGH PVSQESSWSQ EYSFGPSAVL GDFGSSRLIE 180
KECLEKESRD YDVDHPGEAD SVLRGGSQVQ ARGRALNIVD QEGSLLGKGE TQGLLTAKGG 240
VGKLVTLRNV STKKIPTVNR ITPKTQGTNQ IQKNTPSPDV TLGTNPGTED IQFPIQKIPL 300
GLDLKNLRLP RRKMSFDIID KSDVFSRFGI EIIKWAGFHT IKDDIKFSQL FQTLFELETE 360
TCAKMLASFK CSLKPEHRDF CFFTIKFLKH SALKTPRVDN EFLNMLLDKG AVKTKNCFFE 420
IIKPFDKYIM RLQDRLLKSV TPLLMACNAY ELSVKMKTLS NPLDLALALE TTNSLCRKSL 480
ALLGQTFSLA SSFRQEKILE AVGLQDIAPS PAAFPNFEDS TLFGREYIDH LKAWLVSSGC 540
PLQVKKAEPE PMREEEKMIP PTKPEIQAKA PSSLSDAVPQ RADHRVVGTI DQLVKRVIEG 600
SLSPKERTLL KEDPAYWFLS DENSLEYKYY KLKLAEMQRM SENLRGADQK PTSADCAVRA 660
MLYSRAVRNL KKKLLPWQRR GLLRAQGLRG WKARRATTGT QTLLSSGTRL KHHGRQAPGL 720
SQAKPSLPDR NDAAKDCPPD PVGPSPQDPS LEASGPSPKP AGVDISEAPQ TSSPCPSADI 780
DMKTMETAEK LARFVAQVGP EIEQFSIENS TDNPDLWFLH DQNSSAFKFY RKKVFELCPS 840
ICFTSSPHNL HTGGGDTTGS QESPVDLMEG EAEFEDEPPP REAELESPEV MPEEEDEDDE 900
DGGEEAPAPG GAGKSEGSTP ADGLPGEAAE DDLAGAPALS QASSGTCFPR KRISSKSLKV 960
GMIPAPKRVC LIQEPKVHEP VRIAYDRPRG RPMSKKKKPK DLDFAQQKLT DKNLGFQMLQ 1020
KMGWKEGHGL GSLGKGIREP VSVGTPSEGE GLGADGQEHK EDTFDVFRQR MMQMYRHKRA 1080
NK 1082 
Gene Ontology
 GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
 GO:0003723; F:RNA binding; IEA:InterPro.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 
Interpro
 IPR000467; G_patch_dom.
 IPR000061; Surp. 
Pfam
 PF01585; G-patch
 PF01805; Surp 
SMART
 SM00443; G_patch
 SM00648; SWAP 
PROSITE
 PS50174; G_PATCH
 PS50128; SURP 
PRINTS