CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-006082
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Acetyl-CoA hydrolase 
Protein Synonyms/Alias
 Acetyl-CoA deacylase; Acetyl-CoA acylase 
Gene Name
 ACH1 
Gene Synonyms/Alias
 YBL015W; YBL03.18; YBL0304 
Created Date
 July 27, 2013 
Organism
 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 
NCBI Taxa ID
 559292 
Lysine Modification
Position
Peptide
Type
References
343FANWENFKHRLCLRSacetylation[1]
Reference
 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 
Functional Description
 Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation. It may be involved in overall regulation of acetylation during melatonin synthesis. 
Sequence Annotation
 MOD_RES 2 2 Blocked amino end (Thr).
 MOD_RES 350 350 Phosphoserine.  
Keyword
 Complete proteome; Cytoplasm; Direct protein sequencing; Glycoprotein; Hydrolase; Phosphoprotein; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 526 AA 
Protein Sequence
MTISNLLKQR VRYAPYLKKV KEAHELIPLF KNGQYLGWSG FTGVGTPKAV PEALIDHVEK 60
NNLQGKLRFN LFVGASAGPE ENRWAEHDMI IKRAPHQVGK PIAKAINQGR IEFFDKHLSM 120
FPQDLTYGFY TRERKDNKIL DYTIIEATAI KEDGSIVPGP SVGGSPEFIT VSDKVIIEVN 180
TATPSFEGIH DIDMPVNPPF RKPYPYLKVD DKCGVDSIPV DPEKVVAIVE STMRDQVPPN 240
TPSDDMSRAI AGHLVEFFRN EVKHGRLPEN LLPLQSGIGN IANAVIEGLA GAQFKHLTVW 300
TEVLQDSFLD LFENGSLDYA TATSVRLTEK GFDRAFANWE NFKHRLCLRS QVVSNNPEMI 360
RRLGVIAMNT PVEVDIYAHA NSTNVNGSRM LNGLGGSADF LRNAKLSIMH APSARPTKVD 420
PTGISTIVPM ASHVDQTEHD LDILVTDQGL ADLRGLSPKE RAREIINKCA HPDYQALLTD 480
YLDRAEHYAK KHNCLHEPHM LKNAFKFHTN LAEKGTMKVD SWEPVD 526 
Gene Ontology
 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005739; C:mitochondrion; IDA:SGD.
 GO:0008775; F:acetate CoA-transferase activity; IDA:SGD.
 GO:0003986; F:acetyl-CoA hydrolase activity; IDA:SGD.
 GO:0006083; P:acetate metabolic process; IMP:SGD.
 GO:0006084; P:acetyl-CoA metabolic process; IEA:InterPro. 
Interpro
 IPR026888; AcetylCoA_hyd_C.
 IPR003702; ActCoA_hydro.
 IPR017821; Succinate_CoA_transferase. 
Pfam
 PF13336; AcetylCoA_hyd_C
 PF02550; AcetylCoA_hydro 
SMART
  
PROSITE
  
PRINTS