UniProt Accession

 HSDL2_MOUSE; Q2TPA8; Q3ULY5; Q3UVZ3; Q8C3H3; Q99LV2 

Genbank Protein ID

 AY725196; AK085899; AK136773; AK145230; AL806512; BX005031; BX005031; AL806512; BC002211 

Genbank Nucleotide ID

 AAU11505.1; BAC39563.1; BAE23126.1; BAE26313.1; CAM21909.1; CAM21909.1; CAM26657.1; CAM26657.1; AAH02211.1 

Protein Name

 Hydroxysteroid dehydrogenase-like protein 2 

Protein Synonyms/Alias

  

Gene Name

 Hsdl2 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
46	IAAKTTQKHPKLLGT	acetylation	[1]
49	KTTQKHPKLLGTIYT	acetylation	[2]
49	KTTQKHPKLLGTIYT	succinylation	[2]
87	QINSAVEKAVEKFGG	acetylation	[1, 3]
116	NTLDTPTKRVDLMMN	acetylation	[4]
141	KACIPFLKKSKVGHI	acetylation	[1]
295	NDSVPEVKEEKLQLQ	acetylation	[1]
376	VQSMLPQKPHFGAVE	acetylation	[1]
376	VQSMLPQKPHFGAVE	ubiquitination	[5]
390	EETFRIVKDSLSDEV	acetylation	[1]
466	TMAFMSGKLKIKGNI	acetylation	[1]

Reference

 [1] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [5] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Has apparently no steroid dehydrogenase activity (By similarity). 

Sequence Annotation

 DOMAIN 380 487 SCP2.
 NP_BIND 17 23 NADP (By similarity).
 ACT_SITE 168 168 Proton acceptor (Potential).
 BINDING 42 42 NADP (By similarity).
 BINDING 74 74 NADP (By similarity).
 BINDING 172 172 NADP (By similarity).  

Keyword

 Complete proteome; NADP; Oxidoreductase; Peroxisome; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 490 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0005777; C:peroxisome; IEA:UniProtKB-SubCell.
 GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
 GO:0032934; F:sterol binding; IEA:InterPro. 

Interpro

 IPR002198; DH_sc/Rdtase_SDR.
 IPR002347; Glc/ribitol_DH.
 IPR016040; NAD(P)-bd_dom.
 IPR003033; SCP2_sterol-bd_dom. 

Pfam

 PF00106; adh_short
 PF02036; SCP2 

SMART

  

PROSITE

 PS00061; ADH_SHORT 

PRINTS

 PR00081; GDHRDH.