UniProt Accession

 PPR1A_RAT; P19103; Q6DSU5 

Genbank Protein ID

 J05592; AJ276593; AY648296; BC078820 

Genbank Nucleotide ID

 AAA41933.1; CAB77674.1; AAT66740.1; AAH78820.1 

Protein Name

 Protein phosphatase 1 regulatory subunit 1A 

Protein Synonyms/Alias

 Protein phosphatase inhibitor 1; I-1; IPP-1 

Gene Name

 Ppp1r1a 

Gene Synonyms/Alias

 Ipp1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
82	TRTTPTMKELQTMVE	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Inhibitor of protein-phosphatase 1. This protein may be important in hormonal control of glycogen metabolism. Hormones that elevate intracellular cAMP increase I-1 activity in many tissues. I-1 activation may impose cAMP control over proteins that are not directly phosphorylated by PKA. Following a rise in intracellular calcium, I-1 is inactivated by calcineurin (or PP2B). Does not inhibit type-2 phosphatases. 

Sequence Annotation

 REGION 9 12 Essential for activity.
 REGION 42 54 Essential for activity (Probable).
 REGION 143 171 Interaction with PPP1R15A (By
 MOD_RES 1 1 N-acetylmethionine (By similarity).
 MOD_RES 35 35 Phosphothreonine; by PKA (By similarity).
 MOD_RES 67 67 Phosphoserine (By similarity).  

Keyword

 Acetylation; Carbohydrate metabolism; Complete proteome; Glycogen metabolism; Phosphoprotein; Protein phosphatase inhibitor; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 171 AA 

Protein Sequence

Gene Ontology

 GO:0004864; F:protein phosphatase inhibitor activity; IEA:UniProtKB-KW.
 GO:0005977; P:glycogen metabolic process; IEA:UniProtKB-KW.
 GO:0007165; P:signal transduction; IEA:InterPro. 

Interpro

 IPR008466; PPI_1DARPP-32. 

Pfam

 PF05395; DARPP-32 

SMART

  

PROSITE

  

PRINTS