UniProt Accession

 SNR40_MOUSE; Q6PE01; Q3TEJ3; Q9DCX3 

Genbank Protein ID

 AK002371; AK169605; BC058365 

Genbank Nucleotide ID

 BAB22049.1; BAE41255.1; AAH58365.1 

Protein Name

 U5 small nuclear ribonucleoprotein 40 kDa protein 

Protein Synonyms/Alias

 U5 snRNP 40 kDa protein; WD repeat-containing protein 57 

Gene Name

 Snrnp40 

Gene Synonyms/Alias

 Wdr57 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
271	DVRPFAPKERCVKIF	ubiquitination	[1]
287	GNVHNFEKNLLRCSW	acetylation	[2]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441] 

Functional Description

 Component of the U5 small nuclear ribonucleoprotein (snRNP) complex. The U5 snRNP is part of the spliceosome, a multiprotein complex that catalyzes the removal of introns from pre-messenger RNAs (By similarity). 

Sequence Annotation

 REPEAT 65 104 WD 1.
 REPEAT 108 147 WD 2.
 REPEAT 150 190 WD 3.
 REPEAT 192 231 WD 4.
 REPEAT 234 273 WD 5.
 REPEAT 284 323 WD 6.
 REPEAT 326 358 WD 7.  

Keyword

 Complete proteome; mRNA processing; mRNA splicing; Nucleus; Reference proteome; Repeat; Spliceosome; WD repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 358 AA 

Protein Sequence

Gene Ontology

 GO:0071013; C:catalytic step 2 spliceosome; IEA:Compara.
 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0006397; P:mRNA processing; IEA:UniProtKB-KW.
 GO:0008380; P:RNA splicing; IEA:UniProtKB-KW. 

Interpro

 IPR020472; G-protein_beta_WD-40_rep.
 IPR015943; WD40/YVTN_repeat-like_dom.
 IPR001680; WD40_repeat.
 IPR019775; WD40_repeat_CS.
 IPR017986; WD40_repeat_dom. 

Pfam

 PF00400; WD40 

SMART

 SM00320; WD40 

PROSITE

 PS00678; WD_REPEATS_1
 PS50082; WD_REPEATS_2
 PS50294; WD_REPEATS_REGION 

PRINTS

 PR00320; GPROTEINBRPT.