CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038180
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Calcium-independent phospholipase A2-gamma 
Protein Synonyms/Alias
  
Gene Name
 Pnpla8 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
453TSTYTSLKTKLSNVIubiquitination[1]
512QLQLEGMKYIERNDQacetylation[2]
512QLQLEGMKYIERNDQsuccinylation[2]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Hydrolase; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 558 AA 
Protein Sequence
MSQTKEDKQL QDKPDLEERK SSSPGPDTVA DRPDSESPLE VKDKLSSPTQ MPEAHPVSAK 60
QSIANFLSRP TEGVQALVGG YIGGLVPKLK SDPKSPPEEQ EVSAKTEQAV NKDKKAEEKK 120
RVLLQQEKII ARVSIDNRTR ALVQALRRTA DPKLCITRVE ELTFHLLEFP EGKGVAIKEK 180
IIPYLLRLRQ VKDETLQAAV REILALIGYV DPVKGRGIRI LTIDGGGTRG VVALQTLRKL 240
VELTQKPIHQ LFDYICGVST GAILAFMLGL FHMPLDECEE LYRKLGSDVF TQNVIVGTVK 300
MSWSHAFYDS NTWEKILKDR IGSALMIETA RNPACPKVAA ISTIVNRGQT PKAFVFRNYG 360
HFPGTNSHYL GGCQYKMWQA IRASSAAPGY FAEYALGSDL HQDGGLLLNN PSALALHECK 420
CIWPDTPLEC IVSLGTGRYE SDVRNTSTYT SLKTKLSNVI SSATDTEEVH IMLDGLLPSD 480
TYFRFNPVIC ENIPLDESRD EKLDQLQLEG MKYIERNDQK MKKVAKILSQ EKTTLQKIND 540
WIKLKSDMYE GLPFFSKL 558 
Gene Ontology
 GO:0005778; C:peroxisomal membrane; IEA:Compara.
 GO:0047499; F:calcium-independent phospholipase A2 activity; IEA:Compara.
 GO:0019369; P:arachidonic acid metabolic process; IEA:Compara.
 GO:0050482; P:arachidonic acid secretion; IEA:Compara.
 GO:0008219; P:cell death; IEA:Compara.
 GO:0043651; P:linoleic acid metabolic process; IEA:Compara.
 GO:0034638; P:phosphatidylcholine catabolic process; IEA:Compara.
 GO:0046338; P:phosphatidylethanolamine catabolic process; IEA:Compara.
 GO:0001516; P:prostaglandin biosynthetic process; IEA:Compara. 
Interpro
 IPR016035; Acyl_Trfase/lysoPLipase.
 IPR002641; Patatin/PLipase_A2-rel. 
Pfam
 PF01734; Patatin 
SMART
  
PROSITE
  
PRINTS