| Tag | Content |
|---|
| CPLM ID | CPLM-020601 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Exportin-T |
Protein Synonyms/Alias | Exportin(tRNA); tRNA exportin |
Gene Name | Xpot |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 630 | TPLMERFKVLLEKLM | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Mediates the nuclear export of aminoacylated tRNAs. In the nucleus binds to tRNA and to the GTPase Ran in its active GTP- bound form. Docking of this trimeric complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the tRNA from the export receptor. XPOT then return to the nuclear compartment and mediate another round of transport. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). |
Sequence Annotation | MOD_RES 1 1 N-acetylmethionine (By similarity).
MOD_RES 635 635 N6-acetyllysine (By similarity). |
Keyword | Acetylation; Complete proteome; Cytoplasm; Nucleus; Reference proteome; RNA-binding; Transport; tRNA-binding. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 963 AA |
Protein Sequence | MDEQALLGLN PNADSDFRQR ALAYFEQLKI SPDAWQVCAE ALAQKTYSDD HVKFFCFQVL 60
EHQVKYKYSE LSTAQQQLIR ETLLSWLQAQ MQNPQPEKTF IRNKAAQVFA LLFVTEYLTK 120
WPKFFFDILS VVDLNPRGVD LYLRILMAID SELVDRDVVH TSEASGLENT LIKDTMREQC 180
IPNLVESWYQ ILHNYQYTNS EVLCQCLEVV GAYVSWIDLS LIANDRFINM LLGHMSVEVL 240
REEACDCLFE IVNKGMDPVD KMKLVESLCQ VLQTAGFFSI DQEEDLDFVA RFSKLVNGMG 300
QSLIVSWTKL IKNGAVKNAQ EALEAIETKV PLMLQLLVHE DDDISSNIIG FCYDYLHILK 360
QLPVLSDQQK ANVEAIMLAV MKKLTYDEEY NFENEGEDEA MFVEYRKQLK LLLDRLAQVS 420
PELVLASVRR VFSATLQNWQ TTRFMEVEVA VRLLYMLAEA LPVSHGAHFS GDVSKASALQ 480
DMMRTLVTSG VSSYQHTSVT LEFFETVVRY EKFFTVEPQH IPCVLMAFLD HRGLWHSSAK 540
VRSRTAYLFS RFVKSLNKQM NPYIEEILNR IQDLLALSPP ENGYQSLLSS DDQLFIYETA 600
GALIVNSEYP AENKQALMKD LLTPLMERFK VLLEKLMMAQ DEERQASLAD SLNHAVGFAS 660
RTSKAFSNKQ TVKQCGCSQV YLDCLQTFLP ALSCPLQKDV LRSGVRTFLH RMIICLEEEV 720
LPFIPSASEH MLKDCEAKDL QEFIPLINQI TAKFKMQVSP FLQQMFMPLL HAIFEVLLRP 780
AEDNDQSAAL EKQMLRRSYF AFLQTVTGSG MSEVIANQGA ENVEQVLVTI IQGAVDYPDP 840
IAQKTCFIIL SKLVELWGGK DGPVGFADFV YKHIVPACFL APLKQTFDLA DAQTVLALSE 900
CAVTLKTIHL KRGPECVQYL QQEYLPSLQV APEIIQEFCQ ALQQPDAKVF KNYLKVFFQR 960
AKP 963 |
Gene Ontology | |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |