UniProt Accession

 IOJAP_ECOLI; P0AAT6; P05848; P77107 

Genbank Protein ID

 X04516; U82598; U00096; AP009048 

Genbank Nucleotide ID

 CAA28199.1; AAB40837.1; AAC73738.2; BAA35284.2 

Protein Name

 Ribosomal silencing factor RsfS 

Protein Synonyms/Alias

  

Gene Name

 rsfS 

Gene Synonyms/Alias

 rsfA; slm3; ybeB; b0637; JW5090 

Created Date

 July 27, 2013 

Organism

 Escherichia coli (strain K12) 

NCBI Taxa ID

 83333 

Lysine Modification

Position	Peptide	Type	References
13	LQDFVIDKIDDLKGQ	acetylation	[1]
18	IDKIDDLKGQDIIAL	acetylation	[1]

Reference

 [1] Acetyl-Phosphate Is a Critical Determinant of Lysine Acetylation in E. coli.
 Weinert BT, Iesmantavicius V, Wagner SA, Schölz C, Gummesson B, Beli P, Nyström T, Choudhary C.
 Mol Cell. 2013 Jul 25;51(2):265-72. [PMID: 23830618] 

Functional Description

 Functions as a ribosomal silencing factor. Addition to isolated ribosomal subunits partially inhibits their association, preventing translation. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8, preventing association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation. 

Sequence Annotation

  

Keyword

 Complete proteome; Cytoplasm; Reference proteome; Repressor; Translation regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 105 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
 GO:0043023; F:ribosomal large subunit binding; IDA:EcoCyc.
 GO:0042256; P:mature ribosome assembly; IEA:HAMAP.
 GO:0090071; P:negative regulation of ribosome biogenesis; IDA:UniProtKB.
 GO:0017148; P:negative regulation of translation; IDA:UniProtKB. 

Interpro

 IPR004394; Iojap/RsfS.
 IPR025656; Oligomer_dom. 

Pfam

 PF02410; Oligomerisation 

SMART

  

PROSITE

  

PRINTS