CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-040931
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Reticulocalbin-2 
Protein Synonyms/Alias
  
Gene Name
 RCN2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
56EDVDEYVKLGHEEQQubiquitination[1, 2]
64LGHEEQQKRLQAIIKubiquitination[1, 2]
103HYAMQEAKQQFVEYDubiquitination[1, 2, 3, 4]
250PEWILVEKDRFVNDYubiquitination[2, 5]
Reference
 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [5] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961
Functional Description
  
Sequence Annotation
  
Keyword
 Calcium; Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 335 AA 
Protein Sequence
MRLGPRTAAL GLLLLCAAAA GAGKAEELHY PLGERRSDYD REALLGVQED VDEYVKLGHE 60
EQQKRLQAII KKIDLDSDGF LTESELSSWI QMSFKHYAMQ EAKQQFVEYD KNSDDTVTWD 120
EYNIQMYDRV IDFDENTALD DAEEESFRKE FAICKKQSFC FWLLRFNLHL KDKKRFEKAN 180
QDSGPGLSLE EFIAFEHPEE VDYMTEFVIQ EALEEHDKNG DGFVSLEEFL GDYRWDPTAN 240
EDPEWILVEK DRFVNDYDKD NDGRLDPQEL LPWVVPNNQG IAQEEALHLI DEMDLNGDKK 300
LSEEEILENP DLFLTSEATD YGRQLHDDYF YHDEL 335 
Gene Ontology
 GO:0005509; F:calcium ion binding; IEA:InterPro. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR018247; EF_Hand_1_Ca_BS.
 IPR002048; EF_hand_dom. 
Pfam
 PF13202; EF_hand_3
 PF13499; EF_hand_5 
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2 
PRINTS