UniProt Accession

 NUDT8_MOUSE; Q9CR24; Q3TDQ2 

Genbank Protein ID

 AK002605; AK009700; AK045197; AK170076; BC056443 

Genbank Nucleotide ID

 BAB22224.1; BAB26447.1; BAC32259.1; BAE41549.1; AAH56443.1 

Protein Name

 Nucleoside diphosphate-linked moiety X motif 8, mitochondrial 

Protein Synonyms/Alias

 Nudix motif 8 

Gene Name

 Nudt8 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
70	EVSFPGGKCDPDDQD	acetylation	[1]
70	EVSFPGGKCDPDDQD	succinylation	[1]
96	ELGLEVPKEHVWGVL	acetylation	[2]

Reference

 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Probably mediates the hydrolysis of some nucleoside diphosphate derivatives (By similarity). 

Sequence Annotation

 DOMAIN 25 172 Nudix hydrolase.
 MOTIF 70 91 Nudix box.
 METAL 85 85 Magnesium or manganese (By similarity).
 METAL 89 89 Magnesium or manganese (By similarity).  

Keyword

 Complete proteome; Hydrolase; Magnesium; Manganese; Metal-binding; Mitochondrion; Reference proteome; Transit peptide. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 210 AA 

Protein Sequence

Gene Ontology

 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 

Interpro

 IPR000086; NUDIX_hydrolase_dom.
 IPR015797; NUDIX_hydrolase_dom-like. 

Pfam

 PF00293; NUDIX 

SMART

  

PROSITE

 PS51462; NUDIX
 PS00893; NUDIX_BOX 

PRINTS