UniProt Accession

 IRK11_HUMAN; Q14654; B4DWI4; E9PNK0; Q2M1H7; Q58EX3; Q8IW96 

Genbank Protein ID

 D50582; AK301550; AC124798; BC064497; BC040617; BC112358 

Genbank Nucleotide ID

 BAA09131.1; BAG63046.1; AAH64497.1; AAH40617.1; AAI12359.1 

Protein Name

 ATP-sensitive inward rectifier potassium channel 11 

Protein Synonyms/Alias

 IKATP; Inward rectifier K(+) channel Kir6.2; Potassium channel, inwardly rectifying subfamily J member 11 

Gene Name

 KCNJ11 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
332	RYSVDYSKFGNTIKV	ubiquitination	[1, 2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 

Functional Description

 This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. Can be blocked by extracellular barium (By similarity). Subunit of ATP-sensitive potassium channels (KATP). Can form cardiac and smooth muscle-type KATP channels with ABCC9. KCNJ11 forms the channel pore while ABCC9 is required for activation and regulation. 

Sequence Annotation

 MOTIF 130 135 Selectivity filter (By similarity).
 MOD_RES 341 341 Phosphothreonine; by MAPK1.
 MOD_RES 385 385 Phosphoserine; by MAPK1.  

Keyword

 Alternative splicing; Complete proteome; Diabetes mellitus; Disease mutation; Ion channel; Ion transport; Membrane; Phosphoprotein; Polymorphism; Potassium; Potassium transport; Reference proteome; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 390 AA 

Protein Sequence

Gene Ontology

 GO:0008282; C:ATP-sensitive potassium channel complex; IDA:BHF-UCL.
 GO:0005783; C:endoplasmic reticulum; IEA:Compara.
 GO:0005739; C:mitochondrion; IEA:Compara.
 GO:0030315; C:T-tubule; ISS:BHF-UCL.
 GO:0008076; C:voltage-gated potassium channel complex; IDA:BHF-UCL.
 GO:0005524; F:ATP binding; ISS:BHF-UCL.
 GO:0015272; F:ATP-activated inward rectifier potassium channel activity; ISS:BHF-UCL.
 GO:0030955; F:potassium ion binding; TAS:BHF-UCL.
 GO:0006112; P:energy reserve metabolic process; TAS:Reactome.
 GO:0006006; P:glucose metabolic process; IMP:BHF-UCL.
 GO:0046676; P:negative regulation of insulin secretion; IMP:BHF-UCL.
 GO:0010107; P:potassium ion import; ISS:BHF-UCL.
 GO:0042391; P:regulation of membrane potential; IDA:BHF-UCL.
 GO:0033198; P:response to ATP; IDA:BHF-UCL.
 GO:0042493; P:response to drug; IMP:BHF-UCL.
 GO:0033574; P:response to testosterone stimulus; IEA:Compara.
 GO:0044281; P:small molecule metabolic process; TAS:Reactome.
 GO:0007268; P:synaptic transmission; TAS:Reactome. 

Interpro

 IPR014756; Ig_E-set.
 IPR016449; K_chnl_inward-rec_Kir.
 IPR003279; K_chnl_inward-rec_Kir6.2.
 IPR013518; K_chnl_inward-rec_Kir_cyto. 

Pfam

 PF01007; IRK 

SMART

  

PROSITE

  

PRINTS

 PR01332; KIR62CHANNEL.
 PR01320; KIRCHANNEL.