CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-009563
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Gamma-aminobutyric acid receptor subunit alpha-1 
Protein Synonyms/Alias
 GABA(A) receptor subunit alpha-1 
Gene Name
 Gabra1 
Gene Synonyms/Alias
 Gabra-1 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
363VKDPLIKKNNTYAPTubiquitination[1]
390PGLATIAKSATIEPKubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023
Functional Description
 GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. 
Sequence Annotation
 MOD_RES 367 367 Phosphotyrosine.
 MOD_RES 374 374 Phosphotyrosine.
 CARBOHYD 37 37 N-linked (GlcNAc...) (Potential).
 CARBOHYD 137 137 N-linked (GlcNAc...) (Potential).
 DISULFID 165 179 By similarity.  
Keyword
 Cell junction; Cell membrane; Chloride; Chloride channel; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Ligand-gated ion channel; Membrane; Phosphoprotein; Postsynaptic cell membrane; Receptor; Reference proteome; Signal; Synapse; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 455 AA 
Protein Sequence
MKKSRGLSDY LWAWTLILST LSGRSYGQPS QDELKDNTTV FTRILDRLLD GYDNRLRPGL 60
GERVTEVKTD IFVTSFGPVS DHDMEYTIDV FFRQSWKDER LKFKGPMTVL RLNNLMASKI 120
WTPDTFFHNG KKSVAHNMTM PNKLLRITED GTLLYTMRLT VRAECPMHLE DFPMDAHACP 180
LKFGSYAYTR AEVVYEWTRE PARSVVVAED GSRLNQYDLL GQTVDSGIVQ SSTGEYVVMT 240
THFHLKRKIG YFVIQTYLPC IMTVILSQVS FWLNRESVPA RTVFGVTTVL TMTTLSISAR 300
NSLPKVAYAT AMDWFIAVCY AFVFSALIEF ATVNYFTKRG YAWDGKSVVP EKPKKVKDPL 360
IKKNNTYAPT ATSYTPNLAR GDPGLATIAK SATIEPKEVK PETKPPEPKK TFNSVSKIDR 420
LSRIAFPLLF GIFNLVYWAT YLNREPQLKA PTPHQ 455 
Gene Ontology
 GO:0030054; C:cell junction; IEA:UniProtKB-KW.
 GO:0034707; C:chloride channel complex; IEA:UniProtKB-KW.
 GO:0005887; C:integral to plasma membrane; IEA:Compara.
 GO:0045211; C:postsynaptic membrane; IEA:UniProtKB-SubCell.
 GO:0005254; F:chloride channel activity; IEA:UniProtKB-KW.
 GO:0008144; F:drug binding; IEA:Compara.
 GO:0005230; F:extracellular ligand-gated ion channel activity; IEA:InterPro.
 GO:0004890; F:GABA-A receptor activity; IEA:InterPro.
 GO:0007214; P:gamma-aminobutyric acid signaling pathway; IEA:InterPro.
 GO:0051932; P:synaptic transmission, GABAergic; IEA:Compara. 
Interpro
 IPR006028; GABAA_rcpt.
 IPR001390; GABAAa_rcpt.
 IPR005431; GABBAa1_rcpt.
 IPR006202; Neur_chan_lig-bd.
 IPR006201; Neur_channel.
 IPR006029; Neurotrans-gated_channel_TM.
 IPR018000; Neurotransmitter_ion_chnl_CS. 
Pfam
 PF02931; Neur_chan_LBD
 PF02932; Neur_chan_memb 
SMART
  
PROSITE
 PS00236; NEUROTR_ION_CHANNEL 
PRINTS
 PR01079; GABAARALPHA.
 PR01614; GABAARALPHA1.
 PR00253; GABAARECEPTR.
 PR00252; NRIONCHANNEL.