CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018992
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 WW domain-binding protein 2 
Protein Synonyms/Alias
 WBP-2 
Gene Name
 WBP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
62YRVIFLSKGKDAMQSubiquitination[1]
64VIFLSKGKDAMQSFMubiquitination[1, 2]
83LMKDCEIKQPVFGANubiquitination[1]
93VFGANYIKGTVKAEAubiquitination[1]
258PYYPPEDKKTQ****ubiquitination[2, 3]
259YYPPEDKKTQ*****ubiquitination[3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983
Functional Description
  
Sequence Annotation
 DOMAIN 1 84 GRAM.
 MOTIF 196 200 WW-binding 1.
 MOTIF 248 252 WW-binding 2.  
Keyword
 Complete proteome; Reference proteome; Repeat. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 261 AA 
Protein Sequence
MALNKNHSEG GGVIVNNTES ILMSYDHVEL TFNDMKNVPE AFKGTKKGTV YLTPYRVIFL 60
SKGKDAMQSF MMPFYLMKDC EIKQPVFGAN YIKGTVKAEA GGGWEGSASY KLTFTAGGAI 120
EFGQRMLQVA SQASRGEVPS GAYGYSYMPS GAYVYPPPVA NGMYPCPPGY PYPPPPPEFY 180
PGPPMMDGAM GYVQPPPPPY PGPMEPPVSG PDVPSTPAAE AKAAEAAASA YYNPGNPHNV 240
YMPTSQPPPP PYYPPEDKKT Q 261 
Gene Ontology
  
Interpro
 IPR004182; GRAM.
 IPR018826; WW-domain-binding. 
Pfam
 PF02893; GRAM
 PF10349; WWbp 
SMART
  
PROSITE
  
PRINTS