CPLM-005533

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-005533

UniProt Accession

SRR55_DROME; P26686; A4V2U2; E1JIK1; E1JIK2; E1JIK3; E4NKI6; Q24252; Q26277; Q8IH12; Q8ING7; Q8ING8; Q8ING9; Q8MZ66; Q8T0I0; Q9VFT0; Q9VFT1

Genbank Protein ID

X58720; X62599; AE014297; AE014297; AE014297; AE014297; AE014297; AE014297; AE014297; AE014297; AY069302; AY113327; BT001417; BT001482; BT001495; BT001750; BT003286; BT004500; BT125783; S51722

Genbank Nucleotide ID

CAA41556.1; CAA44483.1; AAF54968.1; AAF54969.2; AAN13575.1; AAN13577.1; AAN13578.1; ACZ94900.1; ACZ94901.1; ACZ94902.1; AAL39447.1; AAM29332.1; AAN71172.1; AAN71237.1; AAN71250.1; AAN71505.1; AAO25044.1; AAO42664.1; ADQ89797.1; AAB24629.1

Protein Name

Serine-arginine protein 55

Protein Synonyms/Alias

SRP55; 52 kDa bracketing protein; B52 protein; Protein enhancer of deformed

Gene Name

B52

Gene Synonyms/Alias

E(Dfd); RS55; SR55; CG10851

Created Date

July 27, 2013

Organism

Drosophila melanogaster (Fruit fly)

NCBI Taxa ID

7227

Lysine Modification

Position	Peptide	Type	References
25	RDLERFFKGYGRTRD	acetylation	[1]

Reference

[1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation.
Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C.
Sci Signal. 2011 Jul 26;4(183):ra48. [PMID: 21791702]

Functional Description

Essential for development. May have a critical role in splicing or in controlling alternative splice site use of at least some pre-mRNA in vivo. Not required for all splicing. May play a general role in the condensation or decondensation of chromatin.

Sequence Annotation

DOMAIN 4 74 RRM 1.
DOMAIN 120 193 RRM 2.
MOD_RES 165 165 Phosphoserine.

Keyword

Alternative splicing; Complete proteome; Direct protein sequencing; mRNA processing; mRNA splicing; Nucleus; Phosphoprotein; Reference proteome; Repeat; RNA-binding.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

376 AA

Protein Sequence

MVGSRVYVGG LPYGVRERDL ERFFKGYGRT RDILIKNGYG FVEFEDYRDA DDAVYELNGK 60
ELLGERVVVE PARGTARGSN RDRYDDRYGG RRGGGGGRYN EKNKNSRSSS RYGPPLRTEY 120
RLIVENLSSR VSWQDLKDYM RQAGEVTYAD AHKQRRNEGV VEFASLSDMK TAIEKLDDTE 180
LNGRRIHLVE DRRGGRSGGG GGSGRGRSRS SSSRSRSRSR RRSRSRRSSH SRSKSRSRSK 240
SRGGRSKSKS PVKSRSRSRS RSNKSRDVSK SKSKSHSRTR SRSPKRERDS RSRSRSVSKR 300
ESRSRSRSKS IHRDSRSRPP TVSFKSSFYK FTTMPFFCSD RSASAENKSR SRSRSRSASP 360
KNGNASPDRN NESMDD 376

Gene Ontology

GO:0071013; C:catalytic step 2 spliceosome; IDA:FlyBase.
GO:0016607; C:nuclear speck; IDA:FlyBase.
GO:0005700; C:polytene chromosome; IDA:FlyBase.
GO:0071011; C:precatalytic spliceosome; IDA:FlyBase.
GO:0035327; C:transcriptionally active chromatin; IDA:FlyBase.
GO:0003729; F:mRNA binding; ISS:FlyBase.
GO:0000166; F:nucleotide binding; IEA:InterPro.
GO:0007067; P:mitosis; IMP:FlyBase.
GO:0006376; P:mRNA splice site selection; ISS:FlyBase.
GO:0000381; P:regulation of alternative mRNA splicing, via spliceosome; IMP:FlyBase.

Interpro

IPR012677; Nucleotide-bd_a/b_plait.
IPR000504; RRM_dom.

Pfam

PF00076; RRM_1

SMART

SM00360; RRM

PROSITE

PS50102; RRM

PRINTS