CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-030467
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 RAN binding protein 10, isoform CRA_b 
Protein Synonyms/Alias
 Ran-binding protein 10; cDNA FLJ31165 fis, clone KIDNE1000121, highly similar to Homo sapiens RAN binding protein 10 (RANBP10), mRNA 
Gene Name
 RANBP10 
Gene Synonyms/Alias
 hCG_27136 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
7*MREWRAKVQGTVHCubiquitination[1]
64QEEQASIKNRQKIQKacetylation[2]
64QEEQASIKNRQKIQKubiquitination[1, 3, 4, 5]
71KNRQKIQKLVLEGRVubiquitination[1, 5]
104PNLLFMLKCRQFVEMubiquitination[1]
128SLSSRSPKSQDSYPGubiquitination[1, 3]
251RIVNGAYKHEDLQTDubiquitination[1]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [3] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [4] Methods for quantification of in vivo changes in protein ubiquitination following proteasome and deubiquitinase inhibition.
 Udeshi ND, Mani DR, Eisenhaure T, Mertins P, Jaffe JD, Clauser KR, Hacohen N, Carr SA.
 Mol Cell Proteomics. 2012 May;11(5):148-59. [PMID: 22505724]
 [5] Integrated proteomic analysis of post-translational modifications by serial enrichment.
 Mertins P, Qiao JW, Patel J, Udeshi ND, Clauser KR, Mani DR, Burgess MW, Gillette MA, Jaffe JD, Carr SA.
 Nat Methods. 2013 Jul;10(7):634-7. [PMID: 23749302
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 391 AA 
Protein Sequence
MREWRAKVQG TVHCFPISAR LGEWQAVLQN MVSSYLVHHG YCATATAFAR MTETPIQEEQ 60
ASIKNRQKIQ KLVLEGRVGE AIETTQRFYP GLLEHNPNLL FMLKCRQFVE MVNGTDSEVR 120
SLSSRSPKSQ DSYPGSPSLS PRHGPSSSHM HNTGADSPSC SNGVASTKSK QNHSKYPAPS 180
SSSSSSSSSS SSSPSSVNYS ESNSTDSTKS QHHSSTSNQE TSDSEMEMEA EHYPNGVLGS 240
MSTRIVNGAY KHEDLQTDES SMDDRHPRRQ LCGGNQAATE RIILFGRELQ ALSEQLGREY 300
GKNLAHTEML QDAFSLLAYS DPWSCPVGQQ LDPIQREPVC AALNSAILES QNLPKQPPLM 360
LALGQASECL RLMARAGLGS CSFARVDDYL H 391 
Gene Ontology
 GO:0005881; C:cytoplasmic microtubule; IEA:Compara.
 GO:0005087; F:Ran guanyl-nucleotide exchange factor activity; IEA:Compara.
 GO:0000226; P:microtubule cytoskeleton organization; IEA:Compara. 
Interpro
 IPR013144; CRA_dom.
 IPR024964; CTLH/CRA.
 IPR006595; CTLH_C.
 IPR006594; LisH_dimerisation.
 IPR013720; LisH_dimerisation_subgr. 
Pfam
 PF10607; CLTH
 PF08513; LisH 
SMART
 SM00757; CRA
 SM00668; CTLH
 SM00667; LisH 
PROSITE
 PS50897; CTLH
 PS50896; LISH 
PRINTS