CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-018333
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Cytoskeleton-associated protein 2 
Protein Synonyms/Alias
 CTCL tumor antigen se20-10; Tumor- and microtubule-associated protein 
Gene Name
 CKAP2 
Gene Synonyms/Alias
 LB1; TMAP 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
31EQRRQKLKEHLLRRKubiquitination[1]
38KEHLLRRKTLFAYKQubiquitination[2, 3]
70DQVQEGTKVLKLKTKubiquitination[1, 2, 3]
91MKRPAESKNNTVVGKubiquitination[4]
229NTSSVTVKSNRSSNMubiquitination[1]
294EKELLQSKTALSSVKubiquitination[1]
509IVDILTMKSQEKANLubiquitination[1]
513LTMKSQEKANLGENMubiquitination[1, 4]
604TPYLQSVKKKVQFDGubiquitination[1]
617DGTNSAFKELKFLTPubiquitination[1, 2, 3]
620NSAFKELKFLTPVRRubiquitination[2, 3]
Reference
 [1] Refined preparation and use of anti-diglycine remnant (K-ε-GG) antibody enables routine quantification of 10,000s of ubiquitination sites in single proteomics experiments.
 Udeshi ND, Svinkina T, Mertins P, Kuhn E, Mani DR, Qiao JW, Carr SA.
 Mol Cell Proteomics. 2013 Mar;12(3):825-31. [PMID: 23266961]
 [2] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [3] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [4] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 
Functional Description
 Possesses microtubule stabilizing properties. Involved in regulating aneuploidy, cell cycling, and cell death in a p53/TP53-dependent manner (By similarity). 
Sequence Annotation
 MOD_RES 534 534 Phosphoserine.
 MOD_RES 579 579 Phosphothreonine.
 MOD_RES 582 582 Phosphothreonine.
 MOD_RES 595 595 Phosphoserine.
 MOD_RES 596 596 Phosphothreonine.
 MOD_RES 597 597 Phosphothreonine.
 MOD_RES 599 599 Phosphotyrosine.
 MOD_RES 602 602 Phosphoserine.  
Keyword
 Alternative splicing; Apoptosis; Cell cycle; Complete proteome; Cytoplasm; Cytoskeleton; Microtubule; Phosphoprotein; Polymorphism; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 683 AA 
Protein Sequence
MSTPAVPQDL QLPPSQRAQS AFKEQRRQKL KEHLLRRKTL FAYKQENEML SSSRDQRVVT 60
SEDQVQEGTK VLKLKTKMAD KENMKRPAES KNNTVVGKHC IPLKPSNELT NSTVVIDTHK 120
PKDSNQTPHL LLTEDDPQSQ HMTLSQAFHL KNNSKKKQMT TEKQKQDANM PKKPVLGSYR 180
GQIVQSKINS FRKPLQVKDE SSAATKKLSA TIPKATKPQP VNTSSVTVKS NRSSNMTATT 240
KFVSTTSQNT QLVRPPIRSH HSNTRDTVKQ GISRTSANVT IRKGPHEKEL LQSKTALSSV 300
KTSSSQGIIR NKTLSRSIAS EVIARPASLS NDKLMEKSEP VDQRRHTAGK AIVDSRSAQP 360
KETSEERKAR LSEWKAGKGR VLKRPPNSVV TQHEPAGQNE KPVGSFWTTM AEEDEQRLFT 420
EKVNNTFSEC LNLINEGCPK EDILVTLNDL IKNIPDAKKL VKYWICLALI EPITSPIENI 480
IAIYEKAILA GAQPIEEMRH TIVDILTMKS QEKANLGENM EKSCASKEEV KEVSIEDTGV 540
DVDPEKLEME SKLHRNLLFQ DCEKEQDNKT KDPTHDVKTP NTETRTSCLI KYNVSTTPYL 600
QSVKKKVQFD GTNSAFKELK FLTPVRRSRR LQEKTSKLPD MLKDHYPCVS SLEQLTELGR 660
ETDAFVCRPN AALCRVYYEA DTT 683 
Gene Ontology
 GO:0005813; C:centrosome; IDA:UniProtKB.
 GO:0005881; C:cytoplasmic microtubule; IDA:MGI.
 GO:0000922; C:spindle pole; IEA:UniProtKB-SubCell.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0000281; P:mitotic cytokinesis; IGI:MGI.
 GO:0007026; P:negative regulation of microtubule depolymerization; IEA:Compara.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IGI:MGI. 
Interpro
 IPR026166; CKAP2.
 IPR026165; CKAP2_fam. 
Pfam
  
SMART
  
PROSITE
  
PRINTS