CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-008101
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Paxillin 
Protein Synonyms/Alias
  
Gene Name
 PXN 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
554SLCSGCQKPITGRCIubiquitination[1]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965] 
Functional Description
 Cytoskeletal protein involved in actin-membrane attachment at sites of cell adhesion to the extracellular matrix (focal adhesion). 
Sequence Annotation
 DOMAIN 356 415 LIM zinc-binding 1.
 DOMAIN 416 473 LIM zinc-binding 2.
 DOMAIN 474 533 LIM zinc-binding 3.
 DOMAIN 534 591 LIM zinc-binding 4.
 MOTIF 3 15 LD motif 1.
 MOTIF 144 156 LD motif 2.
 MOTIF 216 228 LD motif 3.
 MOTIF 265 276 LD motif 4.
 MOTIF 333 345 LD motif 5.
 MOD_RES 1 1 N-acetylmethionine.
 MOD_RES 31 31 Phosphotyrosine; by PTK6.
 MOD_RES 83 83 Phosphoserine (By similarity).
 MOD_RES 85 85 Phosphoserine.
 MOD_RES 88 88 Phosphotyrosine (By similarity).
 MOD_RES 106 106 Phosphoserine.
 MOD_RES 118 118 Phosphotyrosine; by PTK6.
 MOD_RES 119 119 Phosphoserine.
 MOD_RES 126 126 Phosphoserine.
 MOD_RES 130 130 Phosphoserine.
 MOD_RES 137 137 Phosphoserine.
 MOD_RES 181 181 Phosphotyrosine.
 MOD_RES 244 244 Phosphoserine; by CDK5.
 MOD_RES 322 322 Phosphoserine.  
Keyword
 3D-structure; Acetylation; Alternative splicing; Cell adhesion; Cell junction; Complete proteome; Cytoplasm; Cytoskeleton; LIM domain; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Zinc. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 591 AA 
Protein Sequence
MDDLDALLAD LESTTSHISK RPVFLSEETP YSYPTGNHTY QEIAVPPPVP PPPSSEALNG 60
TILDPLDQWQ PSSSRFIHQQ PQSSSPVYGS SAKTSSVSNP QDSVGSPCSR VGEEEHVYSF 120
PNKQKSAEPS PTVMSTSLGS NLSELDRLLL ELNAVQHNPP GFPADEANSS PPLPGALSPL 180
YGVPETNSPL GGKAGPLTKE KPKRNGGRGL EDVRPSVESL LDELESSVPS PVPAITVNQG 240
EMSSPQRVTS TQQQTRISAS SATRELDELM ASLSDFKGSW PLEEVVLLVS ISSSVQEGEK 300
YPHPCAARHR TPSLRSPDQP PPCPQFMAQG KTGSSSPPGG PPKPGSQLDS MLGSLQSDLN 360
KLGVATVAKG VCGACKKPIA GQVVTAMGKT WHPEHFVCTH CQEEIGSRNF FERDGQPYCE 420
KDYHNLFSPR CYYCNGPILD KVVTALDRTW HPEHFFCAQC GAFFGPEGFH EKDGKAYCRK 480
DYFDMFAPKC GGCARAILEN YISALNTLWH PECFVCRECF TPFVNGSFFE HDGQPYCEVH 540
YHERRGSLCS GCQKPITGRC ITAMAKKFHP EHFVCAFCLK QLNKGTFKEQ NDKPYCQNCF 600
LKLFC 605 
Gene Ontology
 GO:0005938; C:cell cortex; IEA:UniProtKB-SubCell.
 GO:0005925; C:focal adhesion; IDA:BHF-UCL.
 GO:0030027; C:lamellipodium; IDA:BHF-UCL.
 GO:0005875; C:microtubule associated complex; TAS:ProtInc.
 GO:0005886; C:plasma membrane; IDA:UniProtKB.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0000187; P:activation of MAPK activity; IEA:Compara.
 GO:0048754; P:branching morphogenesis of an epithelial tube; IEA:Compara.
 GO:0007155; P:cell adhesion; NAS:ProtInc.
 GO:0034329; P:cell junction assembly; TAS:Reactome.
 GO:0006928; P:cellular component movement; IEA:Compara.
 GO:0034614; P:cellular response to reactive oxygen species; IEP:BHF-UCL.
 GO:0007010; P:cytoskeleton organization; IEA:Compara.
 GO:0007173; P:epidermal growth factor receptor signaling pathway; TAS:Reactome.
 GO:0048041; P:focal adhesion assembly; IEA:Compara.
 GO:0060396; P:growth hormone receptor signaling pathway; IDA:BHF-UCL.
 GO:0007229; P:integrin-mediated signaling pathway; IEA:Compara.
 GO:0030032; P:lamellipodium assembly; IEA:Compara.
 GO:0006936; P:muscle contraction; TAS:Reactome.
 GO:0018108; P:peptidyl-tyrosine phosphorylation; IEA:Compara.
 GO:0007172; P:signal complex assembly; TAS:ProtInc. 
Interpro
 IPR001904; Paxillin.
 IPR001781; Znf_LIM. 
Pfam
 PF00412; LIM 
SMART
 SM00132; LIM 
PROSITE
 PS00478; LIM_DOMAIN_1
 PS50023; LIM_DOMAIN_2 
PRINTS
 PR00832; PAXILLIN.