CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-016869
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Rab11 family-interacting protein 3 
Protein Synonyms/Alias
 FIP3-Rab11; Rab11-FIP3 
Gene Name
 Rab11fip3 
Gene Synonyms/Alias
 Kiaa0665 
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
969KQDNRNLKEQNDELNubiquitination[1]
Reference
 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Acts as a regulator of endocytic traffic by participating in membrane delivery. Required for the abcission step in cytokinesis, possibly by acting as an 'address tag' delivering recycling endosome membranes to the cleavage furrow during late cytokinesis. Also required for the structural integrity of the endosomal recycling compartment during interphase. 
Sequence Annotation
 DOMAIN 496 531 EF-hand 1.
 DOMAIN 528 563 EF-hand 2.
 DOMAIN 985 1047 FIP-RBD.
 REGION 775 879 ARF-binding domain (ABD) (By similarity).
 MOD_RES 641 641 Phosphoserine (By similarity).
 MOD_RES 829 829 Phosphoserine (By similarity).
 MOD_RES 938 938 Phosphoserine (By similarity).
 MOD_RES 939 939 Phosphoserine (By similarity).  
Keyword
 Alternative splicing; Calcium; Cell cycle; Cell division; Coiled coil; Complete proteome; Cytoplasm; Cytoskeleton; Endosome; Membrane; Metal-binding; Phosphoprotein; Reference proteome; Repeat; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1047 AA 
Protein Sequence
MELCQPTSLS DHDQPASGPQ RGVMGLVGPD APRGWSEEPE EHAQLQRWPE GPNAPICWPE 60
EVEEPHAPSR WAKEPNAPRC SSQEPDESCH LAEELEESDS PRCWPQEPDT PCHLAKELEE 120
PDAPRCLPQE PDTPCYLAKE LEEPNIPRCW PQEPDVPCHL AKELEEPDAP RCWPQEPDAF 180
CHLLKEVEEP DALRCWLQGP DAPCHLAKEL EDLDSPRCWP QEPDESCHLA KELEEPDAPC 240
HLAKELEEPD APRCWPQEPD VPCLLAKKWE ESDAPCLLTE ELEEPDALHC WPQESEAPCL 300
LAKELEEPDA SHSCPQEADT GCLSAKEPEE PDVSHLWQGV PDAPCLLVKE PEEADALHCC 360
WPEESEEPDA LNPPCFWANE PDEPDPSRCW SEEPQVLCLW PEEQNTKRCW QEEPDAPCFW 420
PEDREEPIVS CLQFKEPEKP KVRSSWPEEL EDCCPTRGLP LEPLLADGEL LQACPGPPSD 480
PGPALSLPSE PGTAQEEGAR LRAVFDALDR DGDGFVRIED FIQFATVYGA EQVKDLTQYL 540
DPSGLGVISF EDFYQGIVAI RNGDPDGQLY SVEPVQDEET PACADEFDDF VTYEANEVTD 600
SAYMGSESTY SECETFTDED TSTLVHPELQ PEGDVDSAGG SGVPSECLDT MEEPDHGALL 660
LLPGRSRPHS QAVVMVIGSE EHFEDYGEGN EAELSPETLC DGDGEDPAFL TPSPAKRLSS 720
RKVARYLHQS GTLTMEALED PPPEPVECPE EDIADKVIFL ERRVSELEKD SAAAGEQHGR 780
LRQENLQLVH RANALEEQLK EQEFRAQEKV LEETRKQKEL LCKMEREKSI EIENLQARLQ 840
QLDEENSELR SCTPCLKANI ERLEEEKQKM LDEIEELTQR LSEEQENKRK MGDRLSHERH 900
QFQRDKEATQ ELIEDLRKQL EHLQLLRLEV EQRRGRSSSL GLQEYNSRAR ESELEQEVRR 960
LKQDNRNLKE QNDELNGQII TLSIQGAKSL FSTSFSESLA AEISSVSRDE LMEAIQKQEE 1020
INFRLQDYID RIIVAILETN PSILEVK 1047 
Gene Ontology
 GO:0005813; C:centrosome; ISS:UniProtKB.
 GO:0032154; C:cleavage furrow; ISS:UniProtKB.
 GO:0005825; C:half bridge of spindle pole body; IEA:Compara.
 GO:0016020; C:membrane; IDA:MGI.
 GO:0030496; C:midbody; ISS:UniProtKB.
 GO:0005634; C:nucleus; IEA:Compara.
 GO:0055037; C:recycling endosome; ISS:UniProtKB.
 GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
 GO:0030306; F:ADP-ribosylation factor binding; ISS:UniProtKB.
 GO:0005509; F:calcium ion binding; IEA:InterPro.
 GO:0042803; F:protein homodimerization activity; ISS:UniProtKB.
 GO:0017137; F:Rab GTPase binding; ISS:UniProtKB.
 GO:0000910; P:cytokinesis; ISS:UniProtKB.
 GO:0032456; P:endocytic recycling; ISS:UniProtKB. 
Interpro
 IPR011992; EF-hand-like_dom.
 IPR002048; EF_hand_dom.
 IPR019018; Rab-bd_FIP-RBD. 
Pfam
 PF13499; EF_hand_5
 PF09457; RBD-FIP 
SMART
 SM00054; EFh 
PROSITE
 PS00018; EF_HAND_1
 PS50222; EF_HAND_2
 PS51511; FIP_RBD 
PRINTS