UniProt Accession

 ADT1_RAT; Q05962 

Genbank Protein ID

 X61667; D12770 

Genbank Nucleotide ID

 CAA43842.1; BAA02237.1 

Protein Name

 ADP/ATP translocase 1 

Protein Synonyms/Alias

 ADP,ATP carrier protein 1; Adenine nucleotide translocator 1; ANT 1; Solute carrier family 25 member 4 

Gene Name

 Slc25a4 

Gene Synonyms/Alias

 Ant1 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
23	GIAAAVSKTAVAPIE	acetylation	[1]
33	VAPIERVKLLLQVQH	acetylation	[1]
43	LQVQHASKQISAEKQ	acetylation	[1]
63	DCVVRIPKEQGFLSF	acetylation	[1]
94	LNFAFKDKYKQIFLG	acetylation	[1]
96	FAFKDKYKQIFLGGV	acetylation	[1]
107	LGGVDRHKQFWRYFA	acetylation	[1]
147	RLAADVGKGSSQREF	acetylation	[1]
163	GLGDCLTKIFKSDGL	acetylation	[1]
166	DCLTKIFKSDGLKGL	acetylation	[1]
199	FGVYDTAKGMLPDPK	acetylation	[1]
272	EGRKAFFKGAWSNVL	acetylation	[1]

Reference

 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405] 

Functional Description

 Catalyzes the exchange of cytoplasmic ADP with mitochondrial ATP across the mitochondrial inner membrane. 

Sequence Annotation

 REPEAT 6 98 Solcar 1.
 REPEAT 111 201 Solcar 2.
 REPEAT 212 297 Solcar 3.
 MOTIF 235 240 Substrate recognition (By similarity).
 BINDING 80 80 Nucleotide (By similarity).
 MOD_RES 2 2 N-acetylglycine.
 CROSSLNK 10 10 Glycyl lysine isopeptide (Lys-Gly)  

Keyword

 Acetylation; Complete proteome; Direct protein sequencing; Isopeptide bond; Membrane; Mitochondrion; Mitochondrion inner membrane; Reference proteome; Repeat; Transmembrane; Transmembrane helix; Transport; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 298 AA 

Protein Sequence

Gene Ontology

 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005743; C:mitochondrial inner membrane; IDA:MGI.
 GO:0005741; C:mitochondrial outer membrane; IDA:MGI.
 GO:0000295; F:adenine nucleotide transmembrane transporter activity; TAS:RGD.
 GO:0005471; F:ATP:ADP antiporter activity; IDA:RGD.
 GO:0015866; P:ADP transport; IDA:RGD.
 GO:0015867; P:ATP transport; IDA:RGD.
 GO:0051935; P:L-glutamate uptake involved in synaptic transmission; IEP:RGD.
 GO:2000277; P:positive regulation of oxidative phosphorylation uncoupler activity; IMP:RGD. 

Interpro

 IPR002113; Aden_trnslctor.
 IPR002067; Mit_carrier.
 IPR018108; Mitochondrial_sb/sol_carrier.
 IPR023395; Mt_carrier_dom. 

Pfam

 PF00153; Mito_carr 

SMART

  

PROSITE

 PS50920; SOLCAR 

PRINTS

 PR00927; ADPTRNSLCASE.
 PR00926; MITOCARRIER.