UniProt Accession

 CXCL2_RAT; P30348; Q5WA60 

Genbank Protein ID

 X65647; S77604; U45965; AB060092; S45855 

Genbank Nucleotide ID

 CAA46599.1; AAB33749.1; AAA92438.1; BAB41105.1 

Protein Name

 C-X-C motif chemokine 2 

Protein Synonyms/Alias

 Cytokine-induced neutrophil chemoattractant 3; CINC-3; Macrophage inflammatory protein 2; MIP2 

Gene Name

 Cxcl2 

Gene Synonyms/Alias

 Cinc3; Mip-2; Mip2; Scyb2 

Created Date

 July 27, 2013 

Organism

 Rattus norvegicus (Rat) 

NCBI Taxa ID

 10116 

Lysine Modification

Position	Peptide	Type	References
92	LVQRIVQKILNKGKA	ubiquitination	[1]

Reference

 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 

Functional Description

 Chemotactic for human polymorphonuclear leukocytes but does not induce chemokinesis or an oxidative burst. Contributes to neutrophil activation during inflammation. 

Sequence Annotation

 DISULFID 36 62 By similarity.
 DISULFID 38 78 By similarity.  

Keyword

 Chemotaxis; Complete proteome; Cytokine; Direct protein sequencing; Disulfide bond; Inflammatory response; Reference proteome; Secreted; Signal. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 100 AA 

Protein Sequence

Gene Ontology

 GO:0005615; C:extracellular space; IDA:RGD.
 GO:0008009; F:chemokine activity; IDA:RGD.
 GO:0071347; P:cellular response to interleukin-1; IEP:RGD.
 GO:0071222; P:cellular response to lipopolysaccharide; IEP:RGD.
 GO:0007204; P:elevation of cytosolic calcium ion concentration; IDA:RGD.
 GO:0006955; P:immune response; IEA:InterPro.
 GO:0006954; P:inflammatory response; IEA:UniProtKB-KW.
 GO:0070997; P:neuron death; IDA:RGD.
 GO:0030593; P:neutrophil chemotaxis; IMP:RGD.
 GO:0001975; P:response to amphetamine; IEP:RGD.
 GO:0032355; P:response to estradiol stimulus; IEP:RGD.
 GO:0010332; P:response to gamma radiation; IEP:RGD.
 GO:0051384; P:response to glucocorticoid stimulus; IEP:RGD.
 GO:0009408; P:response to heat; IEP:RGD.
 GO:0042060; P:wound healing; IEP:RGD. 

Interpro

 IPR001089; Chemokine_CXC.
 IPR018048; Chemokine_CXC_CS.
 IPR001811; Chemokine_IL8-like_dom. 

Pfam

 PF00048; IL8 

SMART

 SM00199; SCY 

PROSITE

 PS00471; SMALL_CYTOKINES_CXC 

PRINTS

 PR00437; SMALLCYTKCXC.