UniProt Accession

 IRGM1_MOUSE; Q60766; Q3TJ73 

Genbank Protein ID

 U19119; AK002545; AK167558; AK171743; AL645849; BC145957 

Genbank Nucleotide ID

 AAB48942.1; BAB22176.1; BAE39622.1; BAE42645.1; CAI35117.1; AAI45958.1 

Protein Name

 Immunity-related GTPase family M protein 1 

Protein Synonyms/Alias

 Interferon-inducible GTPase 3; Interferon-inducible protein 1; LPS-stimulated RAW 264.7 macrophage protein 47; LRG-47 

Gene Name

 Irgm1 

Gene Synonyms/Alias

 Ifi1; Iigp3; Irgm 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
57	ERALREGKLLELVYG	ubiquitination	[1]
250	KLRDTLHKDLSNIRC	ubiquitination	[1]
262	IRCCEPLKTLYGTYE	acetylation	[2]
270	TLYGTYEKIVGDKVA	ubiquitination	[1]
275	YEKIVGDKVAVWKQR	ubiquitination	[1]
280	GDKVAVWKQRIANES	ubiquitination	[1]
289	RIANESLKNSLGVRD	ubiquitination	[1]
305	DNMGECLKVYRLIFG	ubiquitination	[1]
393	FLVAQDTKNILEKIL	ubiquitination	[1]
398	DTKNILEKILRDSIF	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [2] Calorie restriction and SIRT3 trigger global reprogramming of the mitochondrial protein acetylome.
 Hebert AS, Dittenhafer-Reed KE, Yu W, Bailey DJ, Selen ES, Boersma MD, Carson JJ, Tonelli M, Balloon AJ, Higbee AJ, Westphall MS, Pagliarini DJ, Prolla TA, Assadi-Porter F, Roy S, Denu JM, Coon JJ.
 Mol Cell. 2013 Jan 10;49(1):186-99. [PMID: 23201123] 

Functional Description

 Putative GTPase which is required for IFNG-mediated clearance of acute protozoan and bacterial infections. Functions in innate immune response probably through regulation of autophagy. May regulate proinflammatory cytokine production and prevent endotoxemia upon infection. Required for macrophage motility and possibly also for adhesion. 

Sequence Annotation

 NP_BIND 84 91 GTP (By similarity).
 NP_BIND 109 113 GTP (By similarity).
 NP_BIND 191 193 GTP (By similarity).
 NP_BIND 232 234 GTP (By similarity).
 REGION 75 289 Mediates targeting to cell membrane and
 REGION 350 374 Mediates targeting to the Golgi.
 MOD_RES 202 202 Phosphoserine.  

Keyword

 Alternative splicing; Autophagy; Cell membrane; Cell projection; Complete proteome; Cytoplasmic vesicle; Endosome; Golgi apparatus; GTP-binding; Hydrolase; Immunity; Innate immunity; Lysosome; Membrane; Nucleotide-binding; Phosphoprotein; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 409 AA 

Protein Sequence

Gene Ontology

 GO:0000421; C:autophagic vacuole membrane; IEA:UniProtKB-SubCell.
 GO:0042995; C:cell projection; IEA:UniProtKB-KW.
 GO:0005783; C:endoplasmic reticulum; TAS:MGI.
 GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
 GO:0005770; C:late endosome; IDA:UniProtKB.
 GO:0031902; C:late endosome membrane; IEA:UniProtKB-SubCell.
 GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
 GO:0005764; C:lysosome; IDA:UniProtKB.
 GO:0001891; C:phagocytic cup; IEA:UniProtKB-SubCell.
 GO:0030670; C:phagocytic vesicle membrane; IEA:UniProtKB-SubCell.
 GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
 GO:0016817; F:hydrolase activity, acting on acid anhydrides; IEA:InterPro.
 GO:0006914; P:autophagy; IEA:UniProtKB-KW.
 GO:0006952; P:defense response; IMP:MGI.
 GO:0045087; P:innate immune response; IEA:UniProtKB-KW. 

Interpro

 IPR007743; Interferon-induced_GTPase.
 IPR027417; P-loop_NTPase. 

Pfam

 PF05049; IIGP 

SMART

  

PROSITE

  

PRINTS