| Tag | Content |
|---|
| CPLM ID | CPLM-012791 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Eukaryotic translation initiation factor 2 subunit 3 |
Protein Synonyms/Alias | Eukaryotic translation initiation factor 2 subunit gamma; eIF-2-gamma |
Gene Name | eIF-2gamma |
Gene Synonyms/Alias | EIF2-GAMMA; eIF2g; CG6476 |
Created Date | July 27, 2013 |
Organism | Drosophila melanogaster (Fruit fly) |
NCBI Taxa ID | 7227 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 436 | TTPVCTEKGEKIALS | acetylation | [1] |
|
Reference | [1] Proteome-wide mapping of the Drosophila acetylome demonstrates a high degree of conservation of lysine acetylation. Weinert BT, Wagner SA, Horn H, Henriksen P, Liu WR, Olsen JV, Jensen LJ, Choudhary C. Sci Signal. 2011 Jul 26;4(183):ra48. [ PMID: 21791702] |
Functional Description | eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2- GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B (By similarity). |
Sequence Annotation | NP_BIND 47 54 GTP (By similarity).
NP_BIND 133 137 GTP (By similarity).
NP_BIND 189 192 GTP (By similarity). |
Keyword | Alternative splicing; Complete proteome; GTP-binding; Initiation factor; Nucleotide-binding; Protein biosynthesis; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 475 AA |
Protein Sequence | MATAEAQIGV NRNLQKQDLS NLDVSKLTPL SPEVISRQAT INIGTIGHVA HGKSTVVKAI 60
SGVQTVRFKN ELERNITIKL GYANAKIYKC DNPKCPRPAS FVSDASSKDD SLPCTRLNCS 120
GNFRLVRHVS FVDCPGHDIL MATMLNGAAV MDAALLLIAG NESCPQPQTS EHLAAIEIMK 180
LKQILILQNK IDLIKESQAK EQYEEITKFV QGTVAEGAPI IPISAQLKYN IDVLCEYIVN 240
KIPVPPRDFN APPRLIVIRS FDVNKPGCEV ADLKGGVAGG SILSGVLKVG QEIEVRPGVV 300
TKDSDGNITC RPIFSRIVSL FAEQNELQYA VPGGLIGVGT KIDPTLCRAD RLVGQVLGAV 360
GQLPDIYQEL EISYYLLRRL LGVRTDGDKK GARVEKLQKN EILLVNIGSL STGGRISATK 420
GDLAKIVLTT PVCTEKGEKI ALSRRVENHW RLIGWGQIFG GKTITPVLDS QVAKK 475 |
Gene Ontology | GO:0005525; F:GTP binding; IEA:UniProtKB-KW. GO:0003924; F:GTPase activity; IEA:InterPro. GO:0003743; F:translation initiation factor activity; IEA:UniProtKB-KW. GO:0006184; P:GTP catabolic process; IEA:GOC. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |