CPLM-018366

CPLM 1.0 - Compendium of Protein Lysine Modification

Tag

Content

CPLM ID

CPLM-018366

UniProt Accession

SORC1_HUMAN; Q8WY21; A2RRF4; Q59GG7; Q5JVT7; Q5JVT8; Q5VY14; Q86WQ1; Q86WQ2; Q9H1Y1; Q9H1Y2

Genbank Protein ID

AF284756; AY099452; AY099453; AB209142; AL160010; AL133395; AL356255; AL356308; AL357333; AL356255; AL133395; AL160010; AL356308; AL357333; AL356308; AL133395; AL160010; AL356255; AL357333; AL357333; AL133395; AL160010; AL356255; AL356308; AL133395; AL160010; AL356255; AL356308; AL357333; AL133395; AL133395; CH471066; BC131597

Genbank Nucleotide ID

AAL56667.1; AAM43811.1; AAM43812.1; BAD92379.1; CAH70582.1; CAH70582.1; CAH70582.1; CAH70582.1; CAH70582.1; CAH73442.1; CAH73442.1; CAH73442.1; CAH73442.1; CAH73442.1; CAI14367.1; CAI14367.1; CAI14367.1; CAI14367.1; CAI14367.1; CAI16407.1; CAI16407.1; CAI16407.1; CAI16407.1; CAI16407.1; CAI40753.1; CAI40753.1; CAI40753.1; CAI40753.1; CAI40753.1; CAI40754.1; CAI40755.1; EAW49583.1; AAI31598.1

Protein Name

VPS10 domain-containing receptor SorCS1

Protein Synonyms/Alias

hSorCS

Gene Name

SORCS1

Gene Synonyms/Alias

SORCS

Created Date

July 27, 2013

Organism

Homo sapiens (Human)

NCBI Taxa ID

9606

Lysine Modification

Position	Peptide	Type	References
700	GAKRIYKKRKSERKC	methylation	[1]
702	KRIYKKRKSERKCMQ	methylation	[1]

Reference

[1] Large-scale global identification of protein lysine methylation in vivo.
Cao XJ, Arnaudo AM, Garcia BA.
Epigenetics. 2013 May 1;8(5):477-85. [PMID: 23644510]

Functional Description

Sequence Annotation

REPEAT 208 219 BNR 1.
REPEAT 256 267 BNR 2.
REPEAT 492 503 BNR 3.
REPEAT 569 580 BNR 4.
REPEAT 611 622 BNR 5.
DOMAIN 803 894 PKD.
CARBOHYD 68 68 O-linked (GalNAc...).
CARBOHYD 184 184 N-linked (GlcNAc...) (Potential).
CARBOHYD 352 352 N-linked (GlcNAc...) (Potential).
CARBOHYD 433 433 N-linked (GlcNAc...) (Potential).
CARBOHYD 765 765 N-linked (GlcNAc...) (Potential).
CARBOHYD 776 776 N-linked (GlcNAc...) (Potential).
CARBOHYD 816 816 N-linked (GlcNAc...) (Potential).
CARBOHYD 847 847 N-linked (GlcNAc...) (Potential).
CARBOHYD 908 908 N-linked (GlcNAc...) (Potential).
CARBOHYD 929 929 N-linked (GlcNAc...) (Potential).

Keyword

Alternative splicing; Complete proteome; Glycoprotein; Membrane; Polymorphism; Reference proteome; Repeat; Signal; Transmembrane; Transmembrane helix.

Sequence Source

UniProt (SWISSPROT/TrEMBL); GenBank; EMBL

Protein Length

1168 AA

Protein Sequence

MGKVGAGGGS QARLSALLAG AGLLILCAPG VCGGGSCCPS PHPSSAPRSA STPRGFSHQG 60
RPGRAPATPL PLVVRPLFSV APGDRALSLE RARGTGASMA VAARSGRRRR SGADQEKAER 120
GEGASRSPRG VLRDGGQQEP GTRERDPDKA TRFRMEELRL TSTTFALTGD SAHNQAMVHW 180
SGHNSSVILI LTKLYDYNLG SITESSLWRS TDYGTTYEKL NDKVGLKTIL SYLYVCPTNK 240
RKIMLLTDPE IESSLLISSD EGATYQKYRL NFYIQSLLFH PKQEDWILAY SQDQKLYSSA 300
EFGRRWQLIQ EGVVPNRFYW SVMGSNKEPD LVHLEARTVD GHSHYLTCRM QNCTEANRNQ 360
PFPGYIDPDS LIVQDHYVFV QLTSGGRPHY YVSYRRNAFA QMKLPKYALP KDMHVISTDE 420
NQVFAAVQEW NQNDTYNLYI SDTRGVYFTL ALENVQSSRG PEGNIMIDLY EVAGIKGMFL 480
ANKKIDNQVK TFITYNKGRD WRLLQAPDTD LRGDPVHCLL PYCSLHLHLK VSENPYTSGI 540
IASKDTAPSI IVASGNIGSE LSDTDISMFV SSDAGNTWRQ IFEEEHSVLY LDQGGVLVAM 600
KHTSLPIRHL WLSFDEGRSW SKYSFTSIPL FVDGVLGEPG EETLIMTVFG HFSHRSEWQL 660
VKVDYKSIFD RRCAEEDYRP WQLHSQGEAC IMGAKRIYKK RKSERKCMQG KYAGAMESEP 720
CVCTEADFDC DYGYERHSNG QCLPAFWFNP SSLSKDCSLG QSYLNSTGYR KVVSNNCTDG 780
VREQYTAKPQ KCPGKAPRGL RIVTADGKLT AEQGHNVTLM VQLEEGDVQR TLIQVDFGDG 840
IAVSYVNLSS MEDGIKHVYQ NVGIFRVTVQ VDNSLGSDSA VLYLHVTCPL EHVHLSLPFV 900
TTKNKEVNAT AVLWPSQVGT LTYVWWYGNN TEPLITLEGS ISFRFTSEGM NTITVQVSAG 960
NAILQDTKTI AVYEEFRSLR LSFSPNLDDY NPDIPEWRRD IGRVIKKSLV EATGVPGQHI 1020
LVAVLPGLPT TAELFVLPYQ DPAGENKRST DDLEQISELL IHTLNQNSVH FELKPGVRVL 1080
VHAAHLTAAP LVDLTPTHSG SAMLMLLSVV FVGLAVFVIY KFKRRVALPS PPSPSTQPGD 1140
SSLRLQRARH ATPPSTPKRG SAGAQYAI 1168

Gene Ontology

GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
GO:0016020; C:membrane; IDA:UniProtKB.
GO:0008188; F:neuropeptide receptor activity; NAS:UniProtKB.

Interpro

IPR022409; PKD/Chitinase_dom.
IPR000601; PKD_dom.
IPR006581; VPS10.

Pfam

PF00801; PKD

SMART

SM00089; PKD
SM00602; VPS10

PROSITE

PS50093; PKD

PRINTS