CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-017298
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 High mobility group protein HMG-I/HMG-Y 
Protein Synonyms/Alias
 HMG-I(Y); High mobility group AT-hook protein 1; High mobility group protein A1 
Gene Name
 Hmga1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
35RPRKQPSKEPSEVPTacetylation[1]
Reference
 [1] Proteomic analysis of lysine acetylation sites in rat tissues reveals organ specificity and subcellular patterns.
 Lundby A, Lage K, Weinert BT, Bekker-Jensen DB, Secher A, Skovgaard T, Kelstrup CD, Dmytriyev A, Choudhary C, Lundby C, Olsen JV.
 Cell Rep. 2012 Aug 30;2(2):419-31. [PMID: 22902405
Functional Description
 HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions (By similarity). 
Sequence Annotation
 DNA_BIND 21 31 A.T hook 1.
 DNA_BIND 53 63 A.T hook 2.
 DNA_BIND 78 89 A.T hook 3.
 REGION 53 77 Interaction with HIPK2 (By similarity).
 MOD_RES 2 2 N-acetylserine (By similarity).
 MOD_RES 15 15 N6-acetyllysine (By similarity).
 MOD_RES 26 26 Asymmetric dimethylarginine; alternate
 MOD_RES 26 26 Omega-N-methylarginine; alternate (By
 MOD_RES 26 26 Symmetric dimethylarginine; alternate (By
 MOD_RES 36 36 Phosphoserine; by HIPK2 and CDC2; in
 MOD_RES 39 39 Phosphothreonine (By similarity).
 MOD_RES 44 44 Phosphoserine (By similarity).
 MOD_RES 49 49 Phosphoserine (By similarity).
 MOD_RES 53 53 Phosphothreonine; by HIPK2 and CDC2; in
 MOD_RES 58 58 Asymmetric dimethylarginine; by PRMT6;
 MOD_RES 58 58 Omega-N-methylarginine; by PRMT6;
 MOD_RES 60 60 Asymmetric dimethylarginine; by PRMT6;
 MOD_RES 60 60 Omega-N-methylarginine; by PRMT6;
 MOD_RES 78 78 Phosphothreonine; by HIPK2 and CDC2; in
 MOD_RES 99 99 Phosphoserine (By similarity).
 MOD_RES 102 102 Phosphoserine (By similarity).
 MOD_RES 103 103 Phosphoserine.  
Keyword
 Acetylation; Alternative splicing; Chromosome; Complete proteome; DNA-binding; Methylation; Nucleus; Phosphoprotein; Reference proteome; Repeat; Transcription; Transcription regulation. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 107 AA 
Protein Sequence
MSESVSKSSQ PLASKQEKDG TEKRGRGRPR KQPSKEPSEV PTPKRPRGRP KGSKNKGTAK 60
TRKVTTTPGR KPRGRPKKLE KEEEEGISQE SSEEEQ 96 
Gene Ontology
 GO:0005634; C:nucleus; ISS:UniProtKB.
 GO:0035985; C:senescence-associated heterochromatin focus; ISS:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0030374; F:ligand-dependent nuclear receptor transcription coactivator activity; ISS:UniProtKB.
 GO:0042975; F:peroxisome proliferator activated receptor binding; ISS:UniProtKB.
 GO:0046965; F:retinoid X receptor binding; ISS:UniProtKB.
 GO:0003700; F:sequence-specific DNA binding transcription factor activity; ISS:UniProtKB.
 GO:0008285; P:negative regulation of cell proliferation; ISS:UniProtKB.
 GO:0045892; P:negative regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0090402; P:oncogene-induced senescence; ISS:UniProtKB.
 GO:2000774; P:positive regulation of cellular senescence; ISS:UniProtKB.
 GO:0045893; P:positive regulation of transcription, DNA-dependent; ISS:UniProtKB.
 GO:0035986; P:senescence-associated heterochromatin focus assembly; ISS:UniProtKB.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 
Interpro
 IPR020478; AT_hook-like.
 IPR017956; AT_hook_DNA-bd_motif.
 IPR000116; HMGI/HMGY.
 IPR000637; HMGI/Y_DNA-bd_CS. 
Pfam
 PF02178; AT_hook 
SMART
 SM00384; AT_hook 
PROSITE
 PS00354; HMGI_Y 
PRINTS
 PR00929; ATHOOK.
 PR00930; HIGHMOBLTYIY.