CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-005073
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Non-specific lipid-transfer protein 
Protein Synonyms/Alias
 NSL-TP; Propanoyl-CoA C-acyltransferase; SCP-chi; SCPX; Sterol carrier protein 2; SCP-2; Sterol carrier protein X; SCP-X 
Gene Name
 SCP2 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
49EEGEQFVKKIGGIFAubiquitination[1]
Reference
 [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization.
 Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW.
 Nature. 2013 Apr 18;496(7445):372-6. [PMID: 23503661] 
Functional Description
 Mediates in vitro the transfer of all common phospholipids, cholesterol and gangliosides between membranes. May play a role in regulating steroidogenesis. 
Sequence Annotation
 DOMAIN 433 543 SCP2.
 MOTIF 545 547 Microbody targeting signal (Potential).
 MOD_RES 142 142 N6-acetyllysine (By similarity).
 MOD_RES 173 173 N6-acetyllysine (By similarity).
 MOD_RES 183 183 N6-acetyllysine.
 MOD_RES 282 282 N6-acetyllysine (By similarity).
 MOD_RES 341 341 N6-acetyllysine (By similarity).
 MOD_RES 425 425 Phosphoserine (By similarity).
 MOD_RES 438 438 N6-acetyllysine.
 MOD_RES 453 453 N6-acetyllysine (By similarity).
 MOD_RES 470 470 N6-acetyllysine.  
Keyword
 3D-structure; Acetylation; Acyltransferase; Alternative initiation; Alternative promoter usage; Alternative splicing; Complete proteome; Cytoplasm; Direct protein sequencing; Lipid transport; Lipid-binding; Mitochondrion; Peroxisome; Phosphoprotein; Polymorphism; Reference proteome; Transferase; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 547 AA 
Protein Sequence
MGFPEAASSF RTHQIEAVPT SSASDGFKAN LVFKEIEKKL EEEGEQFVKK IGGIFAFKVK 60
DGPGGKEATW VVDVKNGKGS VLPNSDKKAD CTITMADSDF LALMTGKMNP QSAFFQGKLK 120
ITGNMGLAMK LQNLQLQPGN AKL 143 
Gene Ontology
 GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
 GO:0005634; C:nucleus; IDA:HPA.
 GO:0005782; C:peroxisomal matrix; TAS:Reactome.
 GO:0043234; C:protein complex; IDA:UniProtKB.
 GO:0015485; F:cholesterol binding; IDA:UniProtKB.
 GO:0036042; F:long-chain fatty acyl-CoA binding; IDA:UniProtKB.
 GO:0070538; F:oleic acid binding; IDA:UniProtKB.
 GO:0008526; F:phosphatidylinositol transporter activity; IDA:UniProtKB.
 GO:0033814; F:propanoyl-CoA C-acyltransferase activity; IEA:EC.
 GO:0036109; P:alpha-linolenic acid metabolic process; TAS:Reactome.
 GO:0006699; P:bile acid biosynthetic process; TAS:Reactome.
 GO:0033540; P:fatty acid beta-oxidation using acyl-CoA oxidase; TAS:Reactome.
 GO:0032959; P:inositol trisphosphate biosynthetic process; IDA:UniProtKB.
 GO:1901373; P:lipid hydroperoxide transport; IDA:UniProtKB.
 GO:0006869; P:lipid transport; IEA:UniProtKB-KW.
 GO:0007031; P:peroxisome organization; IEA:Compara.
 GO:0032385; P:positive regulation of intracellular cholesterol transport; IDA:UniProtKB.
 GO:0045940; P:positive regulation of steroid metabolic process; IDA:UniProtKB.
 GO:0006701; P:progesterone biosynthetic process; IDA:UniProtKB.
 GO:0072659; P:protein localization to plasma membrane; IDA:UniProtKB. 
Interpro
 IPR003033; SCP2_sterol-bd_dom.
 IPR016039; Thiolase-like.
 IPR016038; Thiolase-like_subgr.
 IPR020615; Thiolase_acyl_enz_int_AS.
 IPR020617; Thiolase_C.
 IPR020613; Thiolase_CS.
 IPR020616; Thiolase_N. 
Pfam
 PF02036; SCP2
 PF02803; Thiolase_C
 PF00108; Thiolase_N 
SMART
  
PROSITE
 PS00098; THIOLASE_1
 PS00737; THIOLASE_2
 PS00099; THIOLASE_3 
PRINTS