UniProt Accession

 LITAF_MOUSE; Q9JLJ0; Q9EQI0 

Genbank Protein ID

 AF171100; AF230522; AK018578; AK076162; AK151053; AK159533; BC018559; AF220207 

Genbank Nucleotide ID

 AAF27312.1; AAO49168.1; BAB31289.1; BAC36228.1; BAE30070.1; BAE35161.1; AAH18559.1; AAG44246.1 

Protein Name

 Lipopolysaccharide-induced tumor necrosis factor-alpha factor homolog 

Protein Synonyms/Alias

 LPS-induced TNF-alpha factor homolog; Estrogen-enhanced transcript protein; mEET; LITAF-like protein; NEDD4 WW domain-binding protein 3 

Gene Name

 Litaf 

Gene Synonyms/Alias

 N4wbp3; Tbx1 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
159	KALLGTYKRL*****	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Probable role in regulating transcription of specific genes. May regulate through NFKB1 the expression of the CCL2/MCP-1 chemokine. May play a role in tumor necrosis factor alpha (TNF- alpha) gene expression. 

Sequence Annotation

 MOTIF 20 23 WW-binding.  

Keyword

 Apoptosis; Complete proteome; Lysosome; Membrane; Proto-oncogene; Reference proteome; Transcription; Transcription regulation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 161 AA 

Protein Sequence

Gene Ontology

 GO:0005794; C:Golgi apparatus; ISS:UniProtKB.
 GO:0005765; C:lysosomal membrane; ISO:MGI.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0004871; F:signal transducer activity; ISS:UniProtKB.
 GO:0050699; F:WW domain binding; ISS:UniProtKB.
 GO:0006915; P:apoptotic process; IEA:UniProtKB-KW.
 GO:0071222; P:cellular response to lipopolysaccharide; IMP:MGI.
 GO:0042347; P:negative regulation of NF-kappaB import into nucleus; IMP:MGI.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB.
 GO:0001817; P:regulation of cytokine production; IMP:MGI.
 GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR006629; LITAF. 

Pfam

 PF10601; zf-LITAF-like 

SMART

 SM00714; LITAF 

PROSITE

  

PRINTS