| Tag | Content |
|---|
| CPLM ID | CPLM-008851 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Voltage-dependent calcium channel subunit alpha-2/delta-1 |
Protein Synonyms/Alias | Voltage-gated calcium channel subunit alpha-2/delta-1; Voltage-dependent calcium channel subunit alpha-2-1; Voltage-dependent calcium channel subunit delta-1 |
Gene Name | CACNA2D1 |
Gene Synonyms/Alias | CACNL2A; CCHL2A; MHS3 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 530 | LHPNLQPKEPVTLDF | acetylation | [1] |
|
Reference | [1] Regulation of cellular metabolism by protein lysine acetylation. Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL. Science. 2010 Feb 19;327(5968):1000-4. [ PMID: 20167786] |
Functional Description | The alpha-2/delta subunit of voltage-dependent calcium channels regulates calcium current density and activation/inactivation kinetics of the calcium channel. Plays an important role in excitation-contraction coupling (By similarity). |
Sequence Annotation | DOMAIN 253 430 VWFA.
DOMAIN 446 556 Cache.
MOTIF 259 263 MIDAS-like motif.
METAL 259 259 Divalent metal cation (By similarity).
METAL 261 261 Divalent metal cation (By similarity).
METAL 263 263 Divalent metal cation (By similarity).
CARBOHYD 92 92 N-linked (GlcNAc...) (Potential).
CARBOHYD 136 136 N-linked (GlcNAc...) (Potential).
CARBOHYD 184 184 N-linked (GlcNAc...) (Potential).
CARBOHYD 324 324 N-linked (GlcNAc...) (Potential).
CARBOHYD 348 348 N-linked (GlcNAc...) (Potential).
CARBOHYD 468 468 N-linked (GlcNAc...) (Potential).
CARBOHYD 475 475 N-linked (GlcNAc...) (Potential).
CARBOHYD 604 604 N-linked (GlcNAc...) (Potential).
CARBOHYD 613 613 N-linked (GlcNAc...) (Potential).
CARBOHYD 675 675 N-linked (GlcNAc...) (Potential).
CARBOHYD 781 781 N-linked (GlcNAc...) (Potential).
CARBOHYD 824 824 N-linked (GlcNAc...) (Potential).
CARBOHYD 888 888 N-linked (GlcNAc...) (Potential).
CARBOHYD 895 895 N-linked (GlcNAc...) (Potential).
CARBOHYD 985 985 N-linked (GlcNAc...) (Potential).
CARBOHYD 998 998 N-linked (GlcNAc...) (Potential).
DISULFID 404 1059 Interchain (between alpha-2-1 and delta-1 |
Keyword | Alternative splicing; Calcium; Calcium channel; Calcium transport; Complete proteome; Disulfide bond; Glycoprotein; Ion channel; Ion transport; Membrane; Metal-binding; Polymorphism; Reference proteome; Signal; Transmembrane; Transmembrane helix; Transport; Voltage-gated channel. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 1103 AA |
Protein Sequence | MAAGCLLALT LTLFQSLLIG PSSEEPFPSA VTIKSWVDKM QEDLVTLAKT ASGVNQLVDI 60
YEKYQDLYTV EPNNARQLVE IAARDIEKLL SNRSKALVRL ALEAEKVQAA HQWREDFASN 120
EVVYYNAKDD LDPEKNDSEP GSQRIKPVFI EDANFGRQIS YQHAAVHIPT DIYEGSTIVL 180
NELNWTSALD EVFKKNREED PSLLWQVFGS ATGLARYYPA SPWVDNSRTP NKIDLYDVRR 240
RPWYIQGAAS PKDMLILVDV SGSVSGLTLK LIRTSVSEML ETLSDDDFVN VASFNSNAQD 300
VSCFQHLVQA NVRNKKVLKD AVNNITAKGI TDYKKGFSFA FEQLLNYNVS RANCNKIIML 360
FTDGGEERAQ EIFNKYNKDK KVRVFTFSVG QHNYDRGPIQ WMACENKGYY YEIPSIGAIR 420
INTQEYLDVL GRPMVLAGDK AKQVQWTNVY LDALELGLVI TGTLPVFNIT GQFENKTNLK 480
NQLILGVMGV DVSLEDIKRL TPRFTLCPNG YYFAIDPNGY VLLHPNLQPK EPVTLDFLDA 540
ELENDIKVEI RNKMIDGESG EKTFRTLVKS QDERYIDKGN RTYTWTPVNG TDYSLALVLP 600
TYSFYYIKAK LEETITQARS KKGKMKDSET LKPDNFEESG YTFIAPRDYC NDLKISDNNT 660
EFLLNFNEFI DRKTPNNPSC NADLINRVLL DAGFTNELVQ NYWSKQKNIK GVKARFVVTD 720
GGITRVYPKE AGENWQENPE TYEDSFYKRS LDNDNYVFTA PYFNKSGPGA YESGIMVSKA 780
VEIYIQGKLL KPAVVGIKID VNSWIENFTK TSIRDPCAGP VCDCKRNSDV MDCVILDDGG 840
FLLMANHDDY TNQIGRFFGE IDPSLMRHLV NISVYAFNKS YDYQSVCEPG AAPKQGAGHR 900
SAYVPSVADI LQIGWWATAA AWSILQQFLL SLTFPRLLEA VEMEDDDFTA SLSKQSCITE 960
QTQYFFDNDS KSFSGVLDCG NCSRIFHGEK LMNTNLIFIM VESKGTCPCD TRLLIQAEQT 1020
SDGPNPCDMV KQPRYRKGPD VCFDNNVLED YTDCGGVSGL NPSLWYIIGI QFLLLWLVSG 1080
STHRLL 1086 |
Gene Ontology | GO:0016529; C:sarcoplasmic reticulum; IEA:Compara. GO:0030315; C:T-tubule; IEA:Compara. GO:0005891; C:voltage-gated calcium channel complex; IDA:UniProtKB. GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. GO:0005245; F:voltage-gated calcium channel activity; IDA:BHF-UCL. GO:0051924; P:regulation of calcium ion transport; IDA:BHF-UCL. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |