UniProt Accession

 ST14_MOUSE; P56677 

Genbank Protein ID

 AF042822; BC005496 

Genbank Nucleotide ID

 AAD02230.3; AAH05496.1 

Protein Name

 Suppressor of tumorigenicity 14 protein homolog 

Protein Synonyms/Alias

 Epithin; Serine protease 14 

Gene Name

 St14 

Gene Synonyms/Alias

 Prss14 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
21	QDFGAGLKYNSRLEN	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Degrades extracellular matrix. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site (By similarity). 

Sequence Annotation

 DOMAIN 214 331 CUB 1.
 DOMAIN 340 444 CUB 2.
 DOMAIN 451 488 LDL-receptor class A 1.
 DOMAIN 489 522 LDL-receptor class A 2.
 DOMAIN 523 561 LDL-receptor class A 3.
 DOMAIN 565 604 LDL-receptor class A 4.
 DOMAIN 615 854 Peptidase S1.
 ACT_SITE 656 656 Charge relay system (By similarity).
 ACT_SITE 711 711 Charge relay system (By similarity).
 ACT_SITE 805 805 Charge relay system (By similarity).
 CARBOHYD 107 107 N-linked (GlcNAc...) (Potential).
 CARBOHYD 302 302 N-linked (GlcNAc...) (Potential).
 CARBOHYD 365 365 N-linked (GlcNAc...) (Potential).
 CARBOHYD 421 421 N-linked (GlcNAc...).
 CARBOHYD 489 489 N-linked (GlcNAc...) (Potential).
 CARBOHYD 772 772 N-linked (GlcNAc...) (Potential).
 DISULFID 214 244 By similarity.
 DISULFID 340 366 By similarity.
 DISULFID 397 410 By similarity.
 DISULFID 453 464 By similarity.
 DISULFID 459 477 By similarity.
 DISULFID 471 486 By similarity.
 DISULFID 488 501 By similarity.
 DISULFID 496 514 By similarity.
 DISULFID 508 523 By similarity.
 DISULFID 525 537 By similarity.
 DISULFID 532 550 By similarity.
 DISULFID 544 559 By similarity.
 DISULFID 567 579 By similarity.
 DISULFID 574 593 By similarity.
 DISULFID 587 602 By similarity.
 DISULFID 641 657 By similarity.
 DISULFID 776 790 By similarity.
 DISULFID 801 830 By similarity.  

Keyword

 Complete proteome; Disulfide bond; Glycoprotein; Hydrolase; Membrane; Protease; Reference proteome; Repeat; Serine protease; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 855 AA 

Protein Sequence

Gene Ontology

 GO:0005576; C:extracellular region; IDA:MGI.
 GO:0019897; C:extrinsic to plasma membrane; IDA:MGI.
 GO:0005887; C:integral to plasma membrane; TAS:MGI.
 GO:0004252; F:serine-type endopeptidase activity; IEA:InterPro.
 GO:0008236; F:serine-type peptidase activity; IDA:MGI.
 GO:0016477; P:cell migration; TAS:MGI.
 GO:0006508; P:proteolysis; IEA:UniProtKB-KW. 

Interpro

 IPR000859; CUB_dom.
 IPR023415; LDLR_class-A_CS.
 IPR002172; LDrepeatLR_classA_rpt.
 IPR001254; Peptidase_S1.
 IPR018114; Peptidase_S1_AS.
 IPR017051; Peptidase_S1A_matripase.
 IPR000082; SEA_dom.
 IPR009003; Trypsin-like_Pept_dom. 

Pfam

 PF00431; CUB
 PF00057; Ldl_recept_a
 PF01390; SEA
 PF00089; Trypsin 

SMART

 SM00042; CUB
 SM00192; LDLa
 SM00020; Tryp_SPc 

PROSITE

 PS01180; CUB
 PS01209; LDLRA_1
 PS50068; LDLRA_2
 PS50240; TRYPSIN_DOM
 PS00134; TRYPSIN_HIS
 PS00135; TRYPSIN_SER 

PRINTS