CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-014651
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Calcium-transporting ATPase type 2C member 1 
Protein Synonyms/Alias
 ATPase 2C1; ATP-dependent Ca(2+) pump PMR1 
Gene Name
 Atp2c1 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Rattus norvegicus (Rat) 
NCBI Taxa ID
 10116 
Lysine Modification
Position
Peptide
Type
References
8MKVARFQKIPNVENEubiquitination[1]
229LVRCGKAKGIVIGTGubiquitination[1]
514RDLYQQEKAQMGSAGubiquitination[1]
907RSREKTQKNTTSTPSubiquitination[1]
Reference
 [1] Synaptic protein ubiquitination in rat brain revealed by antibody-based ubiquitome analysis.
 Na CH, Jones DR, Yang Y, Wang X, Xu Y, Peng J.
 J Proteome Res. 2012 Sep 7;11(9):4722-32. [PMID: 22871113] 
Functional Description
 This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of the calcium (By similarity). 
Sequence Annotation
 ACT_SITE 350 350 4-aspartylphosphate intermediate (By
 METAL 644 644 Magnesium (By similarity).
 METAL 648 648 Magnesium (By similarity).  
Keyword
 Alternative splicing; ATP-binding; Calcium; Calcium transport; Complete proteome; Golgi apparatus; Hydrolase; Ion transport; Magnesium; Membrane; Metal-binding; Nucleotide-binding; Reference proteome; Transmembrane; Transmembrane helix; Transport. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 919 AA 
Protein Sequence
MKVARFQKIP NVENETMIPV LTSKRASELA VSEVAGLLQA DLQNGLNKSE VSHRRAFHGW 60
NEFDISEDEP LWKKYISQFK NPLIMLLLAS AVISVLMRQF DDAVSITVAI LIVVTVAFVQ 120
EYRSEKSLEE LSKLVPPECH CVREGKLEHT LARDLVPGDT VCLSVGDRVP ADLRLFEAVD 180
LSIDESSLTG ETTPCSKVTA PQPAATNGDL ASRSNIAFMG TLVRCGKAKG IVIGTGENSE 240
FGEVFKMMQA EEAPKTPLQK SMDLLGKQLS FYSFGIIGII MLVGWLLGKD ILEMFTISVS 300
LAVAAIPEGL PIVVTVTLAL GVMRMVKKRA IVKKLPIVET LGCCNVICSD KTGTLTKNEM 360
TVTHILTSDG LHAEVTGVGY NQFGEVIVDG DVVHGFYNPA VSRIVEAGCV CNDAVIRNNT 420
LMGKPTEGAL IALAMKMGLD GLQQDYIRKA EYPFSSEQKW MAVKCVHRTQ QDRPEICFMK 480
GAYEQVIKYC TTYNSKGQTL ALTQQQRDLY QQEKAQMGSA GLRVLALASG PDLGQLTLLG 540
LVGIIDPPRT GVKEAVTTLI ASGVSIKMIT GDSQETAIAI ASRLGLYSKT SQSVSGEEVD 600
TMEVQHLSQI VPKVAVFYRA SPRHKMKIIK SLQKNGSVVA MTGDGVNDAV ALKAADIGVA 660
MGQTGTDVCK EAADMILVDD DFQTIMSAIE EGKGIYNNIK NFVRFQLSTS IAALTLISLA 720
TLMNFPNPLN AMQILWINII MDGPPAQSLG VEPVDKDVIR KPPRNWKDSI LTKNLILKIL 780
VSSIIIVCGT LFVFWRELRD NVITPRDTTM TFTCFVFFDM FNALSSRSQT KSVFEIGLCS 840
NKMFCYAVLG SIMGQLLVIY FPPLQKVFQT ESLSILDLLF LLGLTSSVCI VSEIIKKVER 900
SREKTQKNTT STPSSFLEV 919 
Gene Ontology
 GO:0000139; C:Golgi membrane; ISS:UniProtKB.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0005886; C:plasma membrane; IDA:RGD.
 GO:0030141; C:secretory granule; IDA:RGD.
 GO:0005802; C:trans-Golgi network; ISS:UniProtKB.
 GO:0030133; C:transport vesicle; IDA:RGD.
 GO:0005524; F:ATP binding; ISS:UniProtKB.
 GO:0005509; F:calcium ion binding; ISS:UniProtKB.
 GO:0005388; F:calcium-transporting ATPase activity; ISS:UniProtKB.
 GO:0030145; F:manganese ion binding; ISS:UniProtKB.
 GO:0015410; F:manganese-transporting ATPase activity; ISS:UniProtKB.
 GO:0004871; F:signal transducer activity; ISS:UniProtKB.
 GO:0031532; P:actin cytoskeleton reorganization; ISS:UniProtKB.
 GO:0070509; P:calcium ion import; IC:RGD.
 GO:0016339; P:calcium-dependent cell-cell adhesion; ISS:UniProtKB.
 GO:0030026; P:cellular manganese ion homeostasis; ISS:UniProtKB.
 GO:0008544; P:epidermis development; ISS:UniProtKB.
 GO:0032468; P:Golgi calcium ion homeostasis; ISS:UniProtKB.
 GO:0032472; P:Golgi calcium ion transport; ISS:UniProtKB.
 GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade; ISS:UniProtKB. 
Interpro
 IPR006413; ATPase_P-typ_Ca-transp_PMR1.
 IPR006068; ATPase_P-typ_cation-transptr_C.
 IPR004014; ATPase_P-typ_cation-transptr_N.
 IPR023299; ATPase_P-typ_cyto_domN.
 IPR018303; ATPase_P-typ_P_site.
 IPR023298; ATPase_P-typ_TM_dom.
 IPR008250; ATPase_P-typ_transduc_dom_A.
 IPR001757; Cation_transp_P_typ_ATPase.
 IPR023214; HAD-like_dom. 
Pfam
 PF00689; Cation_ATPase_C
 PF00690; Cation_ATPase_N
 PF00122; E1-E2_ATPase
 PF00702; Hydrolase 
SMART
 SM00831; Cation_ATPase_N 
PROSITE
 PS00154; ATPASE_E1_E2 
PRINTS
 PR00119; CATATPASE.
 PR00120; HATPASE.