| Tag | Content |
|---|
| CPLM ID | CPLM-006003 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Sodium- and chloride-dependent GABA transporter 2 |
Protein Synonyms/Alias | GAT-2; Sodium- and chloride-dependent GABA transporter 3; GAT-3; Solute carrier family 6 member 13 |
Gene Name | Slc6a13 |
Gene Synonyms/Alias | Gabt2; Gabt3; Gat-3; Gat2; Gat3 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 15 | TTSNGETKPVCPAME | ubiquitination | [1] | | 23 | PVCPAMEKVEEDGTL | ubiquitination | [1] | | 557 | IYKLRTLKGPLRERL | ubiquitination | [1] | | 577 | PAEDLPQKNQPEPTA | ubiquitination | [1] |
|
Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Sodium-dependent GABA and taurine transporter. In presynaptic terminals, regulates GABA signaling termination through GABA uptake. In the liver, may be the major contributor for GABA uptake. Also involved in beta-alanine transport. |
Sequence Annotation | MOD_RES 587 587 Phosphothreonine.
MOD_RES 591 591 Phosphoserine.
CARBOHYD 169 169 N-linked (GlcNAc...) (Potential).
CARBOHYD 173 173 N-linked (GlcNAc...) (Potential).
CARBOHYD 178 178 N-linked (GlcNAc...) (Potential).
CARBOHYD 269 269 N-linked (GlcNAc...) (Potential). |
Keyword | Cell membrane; Complete proteome; Glycoprotein; Membrane; Neurotransmitter transport; Phosphoprotein; Reference proteome; Symport; Transmembrane; Transmembrane helix; Transport. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 602 AA |
Protein Sequence | MENRASGTTS NGETKPVCPA MEKVEEDGTL EREHWNNKME FVLSVAGEII GLGNVWRFPY 60
LCYKNGGGAF FIPYLIFLFT CGIPVFFLET ALGQYTNQGG ITAWRRICPI FEGIGYASQM 120
IVSLLNVYYI VVLAWALFYL FSSFTTDLPW GSCSHEWNTE NCVEFQKAND SMNVTSENAT 180
SPVIEFWERR VLKLSDGIQH LGSLRWELVL CLLLAWIICY FCIWKGVKST GKVVYFTATF 240
PYLMLVVLLI RGVTLPGAAQ GIQFYLYPNI TRLWDPQVWM DAGTQIFFSF AICLGCLTAL 300
GSYNKYHNNC YRDCIALCIL NSSTSFMAGF AIFSILGFMS QEQGVPISEV AESGPGLAFI 360
AYPRAVVMLP FSPLWACCFF FMVVLLGLDS QFVCVESLVT ALVDMYPRVF RKKNRREVLI 420
LIVSVISFFI GLIMLTEGGM YVFQLFDYYA ASGMCLLFVA IFESLCVAWV YGAGRFYDNI 480
EDMIGYKPWP LIKYCWLFFT PAVCLATFLF SLIKYTPLTY NKKYTYPWWG DALGWLLALS 540
SMICIPAWSI YKLRTLKGPL RERLRQLVCP AEDLPQKNQP EPTAPATPMT SLLRLTELES 600
NC 602 |
Gene Ontology | GO:0005887; C:integral to plasma membrane; IEA:InterPro. GO:0005332; F:gamma-aminobutyric acid:sodium symporter activity; IEA:Compara. GO:0042165; F:neurotransmitter binding; IEA:Compara. GO:0005328; F:neurotransmitter:sodium symporter activity; IEA:InterPro. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |