UniProt Accession

 PYRG1_MOUSE; P70698; Q922Y4 

Genbank Protein ID

 U49350; AK148259; BC006698 

Genbank Nucleotide ID

 AAB06942.1; BAE28443.1; AAH06698.1 

Protein Name

 CTP synthase 1 

Protein Synonyms/Alias

 CTP synthetase 1; UTP--ammonia ligase 1 

Gene Name

 Ctps1 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
100	IYQYVINKERKGDYL	acetylation	[1]
100	IYQYVINKERKGDYL	ubiquitination	[2]
306	CSIALVGKYTKFSDS	acetylation	[3]
309	ALVGKYTKFSDSYAS	acetylation	[4]
319	DSYASVIKALEHSAL	ubiquitination	[2]
460	RRTLFQTKNSVMRKL	acetylation	[4]
466	TKNSVMRKLYGDTDY	acetylation	[4]

Reference

 [1] Proteomic investigations of lysine acetylation identify diverse substrates of mitochondrial deacetylase sirt3.
 Sol EM, Wagner SA, Weinert BT, Kumar A, Kim HS, Deng CX, Choudhary C.
 PLoS One. 2012;7(12):e50545. [PMID: 23236377]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023]
 [3] Quantitative acetylome analysis reveals the roles of SIRT1 in regulating diverse substrates and cellular pathways.
 Chen Y, Zhao W, Yang JS, Cheng Z, Luo H, Lu Z, Tan M, Gu W, Zhao Y.
 Mol Cell Proteomics. 2012 Oct;11(10):1048-62. [PMID: 22826441]
 [4] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337] 

Functional Description

 Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. 

Sequence Annotation

 DOMAIN 300 554 Glutamine amidotransferase type-1.
 ACT_SITE 399 399 For GATase activity (By similarity).
 ACT_SITE 526 526 For GATase activity (By similarity).
 ACT_SITE 528 528 For GATase activity (By similarity).
 MOD_RES 100 100 N6-acetyllysine (By similarity).
 MOD_RES 562 562 Phosphoserine (By similarity).
 MOD_RES 566 566 Phosphothreonine.
 MOD_RES 567 567 Phosphotyrosine.
 MOD_RES 568 568 Phosphoserine.
 MOD_RES 571 571 Phosphoserine.
 MOD_RES 573 573 Phosphoserine.
 MOD_RES 574 574 Phosphoserine.
 MOD_RES 575 575 Phosphoserine.
 MOD_RES 587 587 Phosphoserine (By similarity).  

Keyword

 Acetylation; ATP-binding; Complete proteome; Glutamine amidotransferase; Ligase; Nucleotide-binding; Phosphoprotein; Pyrimidine biosynthesis; Reference proteome. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 591 AA 

Protein Sequence

Gene Ontology

 GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
 GO:0003883; F:CTP synthase activity; IEA:EC.
 GO:0044210; P:'de novo' CTP biosynthetic process; IEA:UniProtKB-UniPathway.
 GO:0006541; P:glutamine metabolic process; IEA:UniProtKB-KW. 

Interpro

 IPR004468; CTP_synthase.
 IPR017456; CTP_synthase_N.
 IPR017926; GATASE.
 IPR027417; P-loop_NTPase. 

Pfam

 PF06418; CTP_synth_N
 PF00117; GATase 

SMART

  

PROSITE

 PS51273; GATASE_TYPE_1 

PRINTS