UniProt Accession

 PIN4_HUMAN; Q9Y237; A8E0G6; B3KXM0; F5H1P5; Q0D2H3; Q3MHV0; Q52M21; Q5HYW6; Q6IRW4 

Genbank Protein ID

 AF143096; AB009690; BX119917; AL135749; BC005234; BC070288; BC093700; BC104653; BC111394; BC112281; AM420633; AK127605 

Genbank Nucleotide ID

 AAD27893.1; BAA82320.1; CAI39856.1; CAI39856.1; AAH05234.2; AAH70288.1; AAH93700.1; AAI04654.1; AAI11395.1; AAI12282.1; CAM12362.1; BAG54532.1 

Protein Name

 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 

Protein Synonyms/Alias

 Parvulin-14; Par14; hPar14; Parvulin-17; Par17; hPar17; Peptidyl-prolyl cis-trans isomerase Pin4; PPIase Pin4; Peptidyl-prolyl cis/trans isomerase EPVH; hEPVH; Rotamase Pin4 

Gene Name

 PIN4 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
32	DKKAQGPKGGGNAVK	acetylation	[1]

Reference

 [1] Lysine acetylation targets protein complexes and co-regulates major cellular functions.
 Choudhary C, Kumar C, Gnad F, Nielsen ML, Rehman M, Walther TC, Olsen JV, Mann M.
 Science. 2009 Aug 14;325(5942):834-40. [PMID: 19608861] 

Functional Description

 Isoform 1 is involved as a ribosomal RNA processing factor in ribosome biogenesis. Binds to tightly bent AT-rich stretches of double-stranded DNA. 

Sequence Annotation

 DOMAIN 35 129 PpiC.
 REGION 1 41 Necessary for association with the pre-
 REGION 1 25 Necessary for nuclear localization and
 MOD_RES 19 19 Phosphoserine; by CK2.  

Keyword

 3D-structure; Alternative promoter usage; Complete proteome; Cytoplasm; Cytoskeleton; Direct protein sequencing; DNA-binding; Isomerase; Mitochondrion; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Rotamase; Ubl conjugation. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 131 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IDA:UniProtKB.
 GO:0005759; C:mitochondrial matrix; IDA:UniProtKB.
 GO:0005730; C:nucleolus; IDA:UniProtKB.
 GO:0030684; C:preribosome; IDA:UniProtKB.
 GO:0005819; C:spindle; IDA:UniProtKB.
 GO:0003681; F:bent DNA binding; IDA:UniProtKB.
 GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
 GO:0003690; F:double-stranded DNA binding; IDA:UniProtKB.
 GO:0003755; F:peptidyl-prolyl cis-trans isomerase activity; IEA:UniProtKB-KW.
 GO:0006457; P:protein folding; IEA:UniProtKB-KW.
 GO:0000413; P:protein peptidyl-prolyl isomerization; IEA:GOC.
 GO:0006364; P:rRNA processing; IMP:UniProtKB. 

Interpro

 IPR000297; PPIase_PpiC. 

Pfam

  

SMART

  

PROSITE

 PS01096; PPIC_PPIASE_1
 PS50198; PPIC_PPIASE_2 

PRINTS