UniProt Accession

 TYY1_MOUSE; Q00899 

Genbank Protein ID

 M73963; L13968; L13969; L13965; L13966; L13967; M74590; BC055899 

Genbank Nucleotide ID

 AAA40522.1; AAA40477.1; AAA40477.1; AAA40477.1; AAA40477.1; AAA40477.1; AAA37521.1; AAH55899.1 

Protein Name

 Transcriptional repressor protein YY1 

Protein Synonyms/Alias

 Delta transcription factor; NF-E1; UCR-motif DNA-binding protein; Yin and yang 1; YY-1 

Gene Name

 Yy1 

Gene Synonyms/Alias

 Ucrbp 

Created Date

 July 27, 2013 

Organism

 Mus musculus (Mouse) 

NCBI Taxa ID

 10090 

Lysine Modification

Position	Peptide	Type	References
183	GGKKSGKKSYLGGGA	ubiquitination	[1]

Reference

 [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 

Functional Description

 Multifunctional transcription factor that exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. Binds to the consensus sequence 5'-CCGCCATNTT-3'; some genes have been shown to contain a longer binding motif allowing enhanced binding; the initial CG dinucleotide can be methylated greatly reducing the binding affinity. The effect on transcription regulation is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect activation or repression via cofactor recruitment, or activation or repression by disruption of binding sites or conformational DNA changes. Its activity is regulated by transcription factors and cytoplasmic proteins that have been shown to abrogate or completely inhibit YY1-mediated activation or repression. Binds to the upstream conserved region (UCR) (5'- CGCCATTTT-3') of Moloney murine leukemia virus (MuLV). Proposed to recruit the PRC2/EED-EZH2 complex to target genes that are transcriptional repressed. Involved in DNA repair. In vitro, binds to DNA recombination intermediate structures (Holliday junctions). Involved in spermatogenesis and may play a role in meiotic DNA double-strand break repair. 

Sequence Annotation

 ZN_FING 296 320 C2H2-type 1.
 ZN_FING 325 347 C2H2-type 2.
 ZN_FING 353 377 C2H2-type 3.
 ZN_FING 383 407 C2H2-type 4.
 REGION 257 341 Involved in nuclear matrix association
 REGION 333 371 Involved in repression of activated
 REGION 371 397 Involved in masking transactivation
 METAL 298 298 Zinc 1 (By similarity).
 METAL 303 303 Zinc 1 (By similarity).
 METAL 316 316 Zinc 1 (By similarity).
 METAL 320 320 Zinc 1 (By similarity).
 METAL 327 327 Zinc 2 (By similarity).
 METAL 330 330 Zinc 2 (By similarity).
 METAL 343 343 Zinc 2 (By similarity).
 METAL 347 347 Zinc 2 (By similarity).
 METAL 355 355 Zinc 3 (By similarity).
 METAL 360 360 Zinc 3 (By similarity).
 METAL 373 373 Zinc 3 (By similarity).
 METAL 377 377 Zinc 3 (By similarity).
 METAL 385 385 Zinc 4 (By similarity).
 METAL 390 390 Zinc 4 (By similarity).
 METAL 403 403 Zinc 4 (By similarity).
 METAL 407 407 Zinc 4 (By similarity).
 MOD_RES 120 120 Phosphoserine (By similarity).
 MOD_RES 247 247 Phosphoserine.
 MOD_RES 378 378 Phosphothreonine (By similarity).  

Keyword

 Activator; ADP-ribosylation; Complete proteome; Differentiation; DNA damage; DNA recombination; DNA repair; DNA-binding; Metal-binding; Nucleus; Phosphoprotein; Reference proteome; Repeat; Repressor; Spermatogenesis; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 414 AA 

Protein Sequence

Gene Ontology

 GO:0031011; C:Ino80 complex; IEA:Compara.
 GO:0016363; C:nuclear matrix; IEA:UniProtKB-SubCell.
 GO:0031519; C:PcG protein complex; IDA:MGI.
 GO:0005886; C:plasma membrane; IEA:Compara.
 GO:0005667; C:transcription factor complex; IDA:MGI.
 GO:0000400; F:four-way junction DNA binding; IEA:Compara.
 GO:0003723; F:RNA binding; ISO:MGI.
 GO:0001078; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription; IDA:BHF-UCL.
 GO:0044212; F:transcription regulatory region DNA binding; ISO:MGI.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0009952; P:anterior/posterior pattern specification; IMP:MGI.
 GO:0048593; P:camera-type eye morphogenesis; IGI:MGI.
 GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
 GO:0034644; P:cellular response to UV; IEA:Compara.
 GO:0051276; P:chromosome organization; IMP:UniProtKB.
 GO:0000724; P:double-strand break repair via homologous recombination; IEA:Compara.
 GO:0006974; P:response to DNA damage stimulus; IMP:UniProtKB.
 GO:0034696; P:response to prostaglandin F stimulus; IEA:Compara.
 GO:0010225; P:response to UV-C; IMP:UniProtKB.
 GO:0006403; P:RNA localization; IMP:MGI.
 GO:0007283; P:spermatogenesis; IMP:UniProtKB. 

Interpro

 IPR017114; TF_Yin_yang.
 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

  

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS