| Tag | Content |
|---|
| CPLM ID | CPLM-006127 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Interferon-induced guanylate-binding protein 2 |
Protein Synonyms/Alias | GTP-binding protein 2; GBP-2; HuGBP-2; Guanine nucleotide-binding protein 2 |
Gene Name | GBP2 |
Gene Synonyms/Alias | |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 242 | VFDWPAPKKYLAHLE | ubiquitination | [1] | | 568 | EGFENESKRLQKDIW | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Hydrolyzes GTP to GMP in two consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes (By similarity). |
Sequence Annotation | NP_BIND 45 52 GTP (By similarity).
NP_BIND 67 69 GTP (By similarity).
NP_BIND 97 101 GTP (By similarity).
REGION 1 309 GTPase domain (Globular) (By similarity).
MOD_RES 588 588 Cysteine methyl ester (By similarity).
LIPID 588 588 S-geranylgeranyl cysteine. |
Keyword | Complete proteome; Cytoplasm; Golgi apparatus; GTP-binding; Lipoprotein; Membrane; Methylation; Nucleotide-binding; Nucleus; Polymorphism; Prenylation; Reference proteome. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 591 AA |
Protein Sequence | MAPEINLPGP MSLIDNTKGQ LVVNPEALKI LSAITQPVVV VAIVGLYRTG KSYLMNKLAG 60
KKNGFSLGST VKSHTKGIWM WCVPHPKKPE HTLVLLDTEG LGDIEKGDNE NDSWIFALAI 120
LLSSTFVYNS MGTINQQAMD QLHYVTELTD RIKANSSPGN NSVDDSADFV SFFPAFVWTL 180
RDFTLELEVD GEPITADDYL ELSLKLRKGT DKKSKSFNDP RLCIRKFFPK RKCFVFDWPA 240
PKKYLAHLEQ LKEEELNPDF IEQVAEFCSY ILSHSNVKTL SGGIPVNGPR LESLVLTYVN 300
AISSGDLPCM ENAVLALAQI ENSAAVEKAI AHYEQQMGQK VQLPTETLQE LLDLHRDSER 360
EAIEVFMKNS FKDVDQMFQR KLGAQLEARR DDFCKQNSKA SSDCCMALLQ DIFGPLEEDV 420
KQGTFSKPGG YRLFTQKLQE LKNKYYQVPR KGIQAKEVLK KYLESKEDVA DALLQTDQSL 480
SEKEKAIEVE RIKAESAEAA KKMLEEIQKK NEEMMEQKEK SYQEHVKQLT EKMERDRAQL 540
MAEQEKTLAL KLQEQERLLK EGFENESKRL QKDIWDIQMR SKSLEPICNI L 591 |
Gene Ontology | GO:0005829; C:cytosol; TAS:Reactome. GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell. GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0005525; F:GTP binding; TAS:ProtInc. GO:0003924; F:GTPase activity; IEA:InterPro. GO:0006184; P:GTP catabolic process; IEA:GOC. GO:0060333; P:interferon-gamma-mediated signaling pathway; TAS:Reactome. GO:0060337; P:type I interferon-mediated signaling pathway; TAS:Reactome. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |