UniProt Accession

 ALBU_BOVIN; P02769; A5PJX3; O02787; P04277; Q3SZR2 

Genbank Protein ID

 M73993; X58989; Y17769; AF542068; BC102742; BC142272 

Genbank Nucleotide ID

 AAA51411.1; CAA41735.1; CAA76847.1; AAN17824.1; AAI02743.1; AAI42273.1 

Protein Name

 Serum albumin 

Protein Synonyms/Alias

 BSA; Bos d 6 

Gene Name

 ALB 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Bos taurus (Bovine) 

NCBI Taxa ID

 9913 

Lysine Modification

Position	Peptide	Type	References
28	VFRRDTHKSEIAHRF	glycation	[1, 2]
36	SEIAHRFKDLGEEHF	glycation	[1, 2, 3]
75	NELTEFAKTCVADES	glycation	[1]
88	ESHAGCEKSLHTLFG	glycation	[1, 2]
100	LFGDELCKVASLRET	glycation	[4]
117	DMADCCEKQEPERNE	glycation	[2]
130	NECFLSHKDDSPDLP	glycation	[4]
151	NTLCDEFKADEKKFW	glycation	[4]
156	EFKADEKKFWGKYLY	glycation	[2]
160	DEKKFWGKYLYEIAR	glycation	[2, 3]
183	ELLYYANKYNGVFQE	glycation	[4]
204	KGACLLPKIETMREK	glycation	[2, 4]
228	LRCASIQKFGERALK	glycation	[2]
235	KFGERALKAWSVARL	acetylation	[5]
235	KFGERALKAWSVARL	glycation	[2, 3]
248	RLSQKFPKAEFVEVT	glycation	[4]
256	AEFVEVTKLVTDLTK	glycation	[2, 3]
263	KLVTDLTKVHKECCH	glycation	[4]
266	TDLTKVHKECCHGDL	glycation	[2]
285	DDRADLAKYICDNQD	glycation	[2]
297	NQDTISSKLKECCDK	glycation	[1]
299	DTISSKLKECCDKPL	glycation	[1]
309	CDKPLLEKSHCIAEV	glycation	[4]
346	CKNYQEAKDAFLGSF	glycation	[2]
374	SVLLRLAKEYEATLE	glycation	[2]
399	CYSTVFDKLKHLVDE	glycation	[1, 2]
401	STVFDKLKHLVDEPQ	glycation	[2, 3]
412	DEPQNLIKQNCDQFE	glycation	[1, 2, 4]
420	QNCDQFEKLGEYGFQ	glycation	[1, 2]
437	LIVRYTRKVPQVSTP	acetylation	[5]
437	LIVRYTRKVPQVSTP	glycation	[1, 2]
455	EVSRSLGKVGTRCCT	glycation	[1, 2]
489	RLCVLHEKTPVSEKV	glycation	[1]
495	EKTPVSEKVTKCCTE	glycation	[1, 2, 4]
498	PVSEKVTKCCTESLV	glycation	[1, 2]
523	PDETYVPKAFDEKLF	glycation	[1, 2]
528	VPKAFDEKLFTFHAD	glycation	[1]
548	DTEKQIKKQTALVEL	glycation	[1, 2, 3, 6]
561	ELLKHKPKATEEQLK	glycation	[1, 2]
568	KATEEQLKTVMENFV	glycation	[1, 2]
580	NFVAFVDKCCAADDK	glycation	[4]
587	KCCAADDKEACFAVE	glycation	[1]

Reference

 [1] Site specificity of glycation and carboxymethylation of bovine serum albumin by fructose.
 Hinton DJ, Ames JM.
 Amino Acids. 2006 Jun;30(4):425-34. [PMID: 16583308]
 [2] Analysis of amadori peptides enriched by boronic acid affinity chromatography.
 Frolov A, Hoffmann R.
 Ann N Y Acad Sci. 2008 Apr;1126:253-6. [PMID: 18448825]
 [3] Fragmentation behavior of glycated peptides derived from D-glucose, D-fructose and D-ribose in tandem mass spectrometry.
 Frolov A, Hoffmann P, Hoffmann R.
 J Mass Spectrom. 2006 Nov;41(11):1459-69. [PMID: 17063450]
 [4] Identification of AGE-precursors and AGE formation in glycation-induced BSA peptides.
 Ahmad W, Li L, Deng Y.
 BMB Rep. 2008 Jul 31;41(7):516-22. [PMID: 18682035]
 [5] The application of a hypothesis-driven strategy to the sensitive detection and location of acetylated lysine residues.
 Griffiths JR, Unwin RD, Evans CA, Leech SH, Corfe BM, Whetton AD.
 J Am Soc Mass Spectrom. 2007 Aug;18(8):1423-8. [PMID: 17543536]
 [6] Primary sequence and glycation at lysine-548 of bovine serum albumin.
 Wada Y.
 J Mass Spectrom. 1996 Mar;31(3):263-6. [PMID: 8799278] 

Functional Description

 Serum albumin, the main protein of plasma, has a good binding capacity for water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. 

Sequence Annotation

 DOMAIN 19 209 Albumin 1.
 DOMAIN 210 402 Albumin 2.
 DOMAIN 403 600 Albumin 3.
 METAL 27 27 Copper (By similarity).
 METAL 91 91 Zinc (By similarity).
 METAL 123 123 Zinc (By similarity).
 METAL 270 270 Zinc (By similarity).
 METAL 272 272 Zinc (By similarity).
 MOD_RES 82 82 Phosphoserine (By similarity).
 MOD_RES 442 442 Phosphoserine (By similarity).
 MOD_RES 443 443 Phosphothreonine (By similarity).
 MOD_RES 445 445 Phosphothreonine (By similarity).
 DISULFID 77 86
 DISULFID 99 115
 DISULFID 114 125
 DISULFID 147 192
 DISULFID 191 200
 DISULFID 223 269
 DISULFID 268 276
 DISULFID 288 302
 DISULFID 301 312
 DISULFID 339 384
 DISULFID 383 392
 DISULFID 415 461
 DISULFID 460 471
 DISULFID 484 500
 DISULFID 499 510
 DISULFID 537 582
 DISULFID 581 590  

Keyword

 3D-structure; Allergen; Cleavage on pair of basic residues; Complete proteome; Copper; Direct protein sequencing; Disulfide bond; Lipid-binding; Metal-binding; Phosphoprotein; Polymorphism; Reference proteome; Repeat; Secreted; Signal; Zinc. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 607 AA 

Protein Sequence

Gene Ontology

 GO:0005737; C:cytoplasm; IEA:Compara.
 GO:0005576; C:extracellular region; TAS:Reactome.
 GO:0005615; C:extracellular space; IEA:Compara.
 GO:0070062; C:extracellular vesicular exosome; IEA:Compara.
 GO:0043234; C:protein complex; ISS:UniProtKB.
 GO:0003677; F:DNA binding; ISS:UniProtKB.
 GO:0008144; F:drug binding; ISS:UniProtKB.
 GO:0005504; F:fatty acid binding; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
 GO:0019825; F:oxygen binding; IEA:Compara.
 GO:0030170; F:pyridoxal phosphate binding; ISS:UniProtKB.
 GO:0015643; F:toxic substance binding; ISS:UniProtKB.
 GO:0009267; P:cellular response to starvation; ISS:UniProtKB.
 GO:0019836; P:hemolysis by symbiont of host erythrocytes; ISS:UniProtKB.
 GO:0051659; P:maintenance of mitochondrion location; ISS:UniProtKB.
 GO:0043066; P:negative regulation of apoptotic process; ISS:UniProtKB.
 GO:0006810; P:transport; IEA:InterPro. 

Interpro

 IPR000264; ALB/AFP/VDB.
 IPR001703; Alpha-fetoprotein.
 IPR020858; Serum_albumin-like.
 IPR021177; Serum_albumin/AFP.
 IPR020857; Serum_albumin_CS.
 IPR014760; Serum_albumin_N. 

Pfam

 PF00273; Serum_albumin 

SMART

 SM00103; ALBUMIN 

PROSITE

 PS00212; ALBUMIN_1
 PS51438; ALBUMIN_2 

PRINTS

 PR00803; AFETOPROTEIN.
 PR00802; SERUMALBUMIN.