UniProt Accession

 MOT3_YEAST; P54785; D6VZP4 

Genbank Protein ID

 U25279; Z48952; AY693209; BK006946 

Genbank Nucleotide ID

 AAC49982.1; CAA88795.1; AAT93228.1; DAA09968.1 

Protein Name

 Transcriptional activator/repressor MOT3 

Protein Synonyms/Alias

 Hypoxic gene repressor protein 7; Modulator of transcription protein 3 

Gene Name

 MOT3 

Gene Synonyms/Alias

 ROX7; YMR070W; YM9916.09 

Created Date

 July 27, 2013 

Organism

 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) 

NCBI Taxa ID

 559292 

Lysine Modification

Position	Peptide	Type	References
474	INDGVLNKDDVKRVL	acetylation	[1]

Reference

 [1] Proteome-wide analysis of lysine acetylation suggests its broad regulatory scope in Saccharomyces cerevisiae.
 Henriksen P, Wagner SA, Weinert BT, Sharma S, Bacinskaja G, Rehman M, Juffer AH, Walther TC, Lisby M, Choudhary C.
 Mol Cell Proteomics. 2012 Nov;11(11):1510-22. [PMID: 22865919] 

Functional Description

 Transcription factor that affects the expression of a large set of genes. Recognizes and binds to the consensus sequence 5'-[CAT]AGG[TC]A-3' in the promoter region. Plays a major role in the repression of a specific subset of hypoxic genes (e.g. ANB1, DAN1 and HEM13) under aerobic conditions. Acts synergistically with the transcription factor ROX1 to recruit the general repression complex SSN6-TUP1 to the promoter of hypoxic genes. Represses transcription of ergosterol biosynthetic genes. Negatively regulates pheromone-induced gene expression. Can act as a transcriptional activator (e.g. of genes like CYC1, SUC2 and the Ty long terminal repeat delta promoter). 

Sequence Annotation

 ZN_FING 346 368 C2H2-type 1.
 ZN_FING 374 397 C2H2-type 2.
 REGION 98 295 Prion domain (PrD).  

Keyword

 Activator; Amyloid; Complete proteome; Metal-binding; Nucleus; Prion; Reference proteome; Repeat; Repressor; Transcription; Transcription regulation; Zinc; Zinc-finger. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 490 AA 

Protein Sequence

Gene Ontology

 GO:0005829; C:cytosol; IDA:SGD.
 GO:0005634; C:nucleus; IDA:SGD.
 GO:0000978; F:RNA polymerase II core promoter proximal region sequence-specific DNA binding; IDA:SGD.
 GO:0001103; F:RNA polymerase II repressing transcription factor binding; IMP:SGD.
 GO:0008270; F:zinc ion binding; IEA:InterPro.
 GO:0071474; P:cellular hyperosmotic response; IMP:SGD.
 GO:0010895; P:negative regulation of ergosterol biosynthetic process; IMP:SGD.
 GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0045944; P:positive regulation of transcription from RNA polymerase II promoter; IMP:SGD.
 GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW. 

Interpro

 IPR007087; Znf_C2H2.
 IPR015880; Znf_C2H2-like.
 IPR013087; Znf_C2H2/integrase_DNA-bd. 

Pfam

 PF00096; zf-C2H2 

SMART

 SM00355; ZnF_C2H2 

PROSITE

 PS00028; ZINC_FINGER_C2H2_1
 PS50157; ZINC_FINGER_C2H2_2 

PRINTS