CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-022579
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Ankyrin repeat and FYVE domain-containing protein 1 
Protein Synonyms/Alias
 Ankyrin repeats hooked to a zinc finger motif 
Gene Name
 ANKFY1 
Gene Synonyms/Alias
 ANKHZN; KIAA1255 
Created Date
 July 27, 2013 
Organism
 Homo sapiens (Human) 
NCBI Taxa ID
 9606 
Lysine Modification
Position
Peptide
Type
References
900KSAEAILKRESGAAEubiquitination[1, 2]
1193IIKFDLNKPVRVCNIubiquitination[1, 2]
Reference
 [1] Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass.
 Povlsen LK, Beli P, Wagner SA, Poulsen SL, Sylvestersen KB, Poulsen JW, Nielsen ML, Bekker-Jensen S, Mailand N, Choudhary C.
 Nat Cell Biol. 2012 Oct;14(10):1089-98. [PMID: 23000965]
 [2] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789] 
Functional Description
  
Sequence Annotation
 DOMAIN 68 130 BTB.
 REPEAT 217 247 ANK 1.
 REPEAT 255 284 ANK 2.
 REPEAT 288 317 ANK 3.
 REPEAT 322 362 ANK 4.
 REPEAT 366 396 ANK 5.
 REPEAT 490 519 ANK 6.
 REPEAT 542 572 ANK 7.
 REPEAT 588 617 ANK 8.
 REPEAT 621 650 ANK 9.
 REPEAT 654 683 ANK 10.
 REPEAT 687 716 ANK 11.
 REPEAT 724 753 ANK 12.
 REPEAT 769 798 ANK 13.
 REPEAT 802 832 ANK 14.
 REPEAT 836 865 ANK 15.
 REPEAT 870 899 ANK 16.
 REPEAT 905 934 ANK 17.
 REPEAT 938 967 ANK 18.
 REPEAT 971 1001 ANK 19.
 REPEAT 1005 1037 ANK 20.
 REPEAT 1043 1072 ANK 21.
 ZN_FING 1104 1164 FYVE-type.
 MOD_RES 2 2 N-acetylalanine.  
Keyword
 Acetylation; Alternative splicing; ANK repeat; Complete proteome; Cytoplasm; Direct protein sequencing; Endosome; Membrane; Metal-binding; Reference proteome; Repeat; Zinc; Zinc-finger. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 1169 AA 
Protein Sequence
MPTPRDCGRL RSRAGRSRAG AACSRGAPRA AREALDCRRC RDAGGKEVAK LEKHLMLLRQ 60
EYVKLQKKLA ETEKRCALLA AQANKESSSE SFISRLLAIV ADLYEQEQYS DLKIKVGDRH 120
ISAHKFVLAA RSDSWSLANL SSTKELDLSD ANPEVTMTML RWIYTDELEF REDDVFLTEL 180
MKLANRFQLQ LLRERCEKGV MSLVNVRNCI RFYQTAEELN ASTLMNYCAE IIASHWDDLR 240
KEDFSSMSAQ LLYKMIKSKT EYPLHKAIKV EREDVVFLYL IEMDSQLPGK LNEADHNGDL 300
ALDLALSRRL ESIATTLVSH KADVDMVDKS GWSLLHKGIQ RGDLFAATFL IKNGAFVNAA 360
TLGAQETPLH LVALYSSKKH SADVMSEMAQ IAEALLQAGA NPNMQDSKGR TPLHVSIMAG 420
NEYVFSQLLQ CKQLDLELKD HEGSTALWLA VQHITVSSDQ SVNPFEDVPV VNGTSFDENS 480
FAARLIQRGS HTDAPDTATG NCLLQRAAGA GNEAAALFLA TNGAHVNHRN KWGETPLHTA 540
CRHGLANLTA ELLQQGANPN LQTEEALPLP KEAASLTSLA DSVHLQTPLH MAIAYNHPDV 600
VSVILEQKAN ALHATNNLQI IPDFSLKDSR DQTVLGLALW TGMHTIAAQL LGSGAAINDT 660
MSDGQTLLHM AIQRQDSKSA LFLLEHQADI NVRTQDGETA LQLAIRNQLP LVVDAICTRG 720
ADMSVPDEKG NPPLWLALAN NLEDIASTLV RHGCDATCWG PGPGGCLQTL LHRAIDENNE 780
PTACFLIRSG CDVNSPRQPG ANGEGEEEAR DGQTPLHLAA SWGLEETVQC LLEFGANVNA 840
QDAEGRTPIH VAISSQHGVI IQLLVSHPDI HLNVRDRQGL TPFACAMTFK NNKSAEAILK 900
RESGAAEQVD NKGRNFLHVA VQNSDIESVL FLISVHANVN SRVQDASKLT PLHLAVQAGS 960
EIIVRNLLLA GAKVNELTKH RQTALHLAAQ QDLPTICSVL LENGVDFAAV DENGNNALHL 1020
AVMHGRLNNI RVLLTECTVD AEAFNLRGQS PLHILGQYGK ENAAAIFDLF LECMPGYPLD 1080
KPDADGSTVL LLAYMKGNAN LCRAIVRSGA RLGVNNNQGV NIFNYQVATK QLLFRLLDML 1140
SKEPPWCDGS YCYECTARFG VTTRKHHCRH CGRLLCHKCS TKEIPIIKFD LNKPVRVCNI 1200
CFDVLTLGGV S 1211 
Gene Ontology
 GO:0010008; C:endosome membrane; ISS:UniProtKB.
 GO:0046872; F:metal ion binding; IEA:UniProtKB-KW. 
Interpro
 IPR002110; Ankyrin_rpt.
 IPR020683; Ankyrin_rpt-contain_dom.
 IPR000210; BTB/POZ-like.
 IPR011333; BTB/POZ_fold.
 IPR013069; BTB_POZ.
 IPR000306; Znf_FYVE.
 IPR017455; Znf_FYVE-rel.
 IPR011011; Znf_FYVE_PHD.
 IPR013083; Znf_RING/FYVE/PHD. 
Pfam
 PF12796; Ank_2
 PF00651; BTB
 PF01363; FYVE 
SMART
 SM00248; ANK
 SM00225; BTB
 SM00064; FYVE 
PROSITE
 PS50297; ANK_REP_REGION
 PS50088; ANK_REPEAT
 PS50097; BTB
 PS50178; ZF_FYVE 
PRINTS
 PR01415; ANKYRIN.