| Tag | Content |
|---|
| CPLM ID | CPLM-021350 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Protein unc-45 homolog A |
Protein Synonyms/Alias | Unc-45A; GCUNC-45; Smooth muscle cell-associated protein 1; SMAP-1 |
Gene Name | UNC45A |
Gene Synonyms/Alias | SMAP1 |
Created Date | July 27, 2013 |
Organism | Homo sapiens (Human) |
NCBI Taxa ID | 9606 |
Lysine Modification | Position | Peptide | Type | References |
|---|
| 306 | NALTLLIKAVPRKSL | ubiquitination | [1] | | 692 | GTDVGQTKAAQALAK | ubiquitination | [1] |
|
Reference | [1] Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization. Sarraf SA, Raman M, Guarani-Pereira V, Sowa ME, Huttlin EL, Gygi SP, Harper JW. Nature. 2013 Apr 18;496(7445):372-6. [ PMID: 23503661] |
Functional Description | Acts as co-chaperone for HSP90. Prevents the stimulation of HSP90AB1 ATPase activity by AHSA1. Positive factor in promoting PGR function in the cell. May be necessary for proper folding of myosin (Potential). Necessary for normal cell proliferation. Necessary for normal myotube formation and myosin accumulation during muscle cell development. May play a role in erythropoiesis in stroma cells in the spleen (By similarity). |
Sequence Annotation | REPEAT 21 54 TPR 1.
REPEAT 58 91 TPR 2.
REPEAT 92 125 TPR 3.
MOD_RES 15 15 Phosphothreonine.
MOD_RES 70 70 N6-acetyllysine.
MOD_RES 483 483 N6-acetyllysine. |
Keyword | 3D-structure; Acetylation; Alternative splicing; Chaperone; Complete proteome; Cytoplasm; Developmental protein; Differentiation; Myogenesis; Nucleus; Phosphoprotein; Polymorphism; Reference proteome; Repeat; TPR repeat. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 944 AA |
Protein Sequence | MTASSVEQLR KEGNELFKCG DYGGALAAYT QALGLDATPQ DQAVLHRNRA ACHLKLEDYD 60
KAETEASKAI EKDGGDVKAL YRRSQALEKL GRLDQAVLDL QRCVSLEPKN KVFQEALRNI 120
GGQIQEKVRY MSSTDAKVEQ MFQILLDPEE KGTEKKQKAS QNLVVLARED AGAEKIFRSN 180
GVQLLQRLLD MGETDLMLAA LRTLVGICSE HQSRTVATLS ILGTRRVVSI LGVESQAVSL 240
AACHLLQVMF DALKEGVKKG FRGKEGAIIV DPARELKVLI SNLLDLLTEV GVSGQGRDNA 300
LTLLIKAVPR KSLKDPNNSL TLWVIDQGLK KILEVGGSLQ DPPGELAVTA NSRMSASILL 360
SKLFDDLKCD AERENFHRLC ENYIKSWFEG QGLAGKLRAI QTVSCLLQGP CDAGNRALEL 420
SGVMESVIAL CASEQEEEQL VAVEALIHAA GKAKRASFIT ANGVSLLKDL YKCSEKDSIR 480
IRALVGLCKL GSAGGTDFSM KQFAEGSTLK LAKQCRKWLC NDQIDAGTRR WAVEGLAYLT 540
FDADVKEEFV EDAAALKALF QLSRLEERSV LFAVASALVN CTNSYDYEEP DPKMVELAKY 600
AKQHVPEQHP KDKPSFVRAR VKKLLAAGVV SAMVCMVKTE SPVLTSSCRE LLSRVFLALV 660
EEVEDRGTVV AQGGGRALIP LALEGTDVGQ TKAAQALAKL TITSNPEMTF PGERIYEVVR 720
PLVSLLHLNC SGLQNFEALM ALTNLAGISE RLRQKILKEK AVPMIEGYMF EEHEMIRRAA 780
TECMCNLAMS KEVQDLFEAQ GNDRLKLLVL YSGEDDELLQ RAAAGGLAML TSMRPTLCSR 840
IPQVTTHWLE ILQALLLSSN QELQHRGAVV VLNMVEASRE IASTLMESEM MEILSVLAKG 900
DHSPVTRAAA ACLDKAVEYG LIQPNQDGE 929 |
Gene Ontology | GO:0005634; C:nucleus; IEA:UniProtKB-SubCell. GO:0048471; C:perinuclear region of cytoplasm; IEA:UniProtKB-SubCell. GO:0030154; P:cell differentiation; IEA:UniProtKB-KW. GO:0061077; P:chaperone-mediated protein folding; IEA:Compara. GO:0007517; P:muscle organ development; IEA:UniProtKB-KW. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |