UniProt Accession

 HYEP_HUMAN; P07099; Q5VTJ6; Q9NP75; Q9NPE7; Q9NQU6; Q9NQU7; Q9NQU8; Q9NQU9; Q9NQV0; Q9NQV1; Q9NQV2 

Genbank Protein ID

 J03518; X07936; Y00424; L25878; L25879; U06661; U06656; U06657; U06658; U06659; U06660; AL591895; AY948961; BC003567; BC008291; BC095430; M36374; AF253417; AF276626; AF276627; AF276628; AF276629; AF276630; AF276631; AF276632; AF276633; AF276634; AF276635; AF276636; AF276637; AF276638 

Genbank Nucleotide ID

 AAA61305.1; CAA30759.1; CAA68486.1; AAA52389.1; AAA52390.1; AAB60649.1; AAB60649.1; AAB60649.1; AAB60649.1; AAB60649.1; AAB60649.1; CAH71994.1; AAX81410.1; AAH03567.1; AAH08291.1; AAH95430.1; AAA59580.1; AAC41694.1; AAF87726.1; AAF87727.1; AAF87728.1; AAF87729.1; AAF87730.1; AAF87731.1; AAF87732.1; AAF87733.1; AAF87734.1; AAF87735.1; AAF87736.1; AAF87737.1; AAF87738.1 

Protein Name

 Epoxide hydrolase 1 

Protein Synonyms/Alias

 Epoxide hydratase; Microsomal epoxide hydrolase 

Gene Name

 EPHX1 

Gene Synonyms/Alias

 EPHX; EPOX 

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
52	DDSIRPFKVETSDEE	ubiquitination	[1, 2, 3, 4]
131	DIHFIHVKPPQLPAG	acetylation	[5]
286	VELLYPVKEKVFYSL	ubiquitination	[2]
386	GQGWMTQKHERMKVY	ubiquitination	[2]

Reference

 [1] A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles.
 Wagner SA, Beli P, Weinert BT, Nielsen ML, Cox J, Mann M, Choudhary C.
 Mol Cell Proteomics. 2011 Oct;10(10):M111.013284. [PMID: 21890473]
 [2] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983]
 [3] Proteome-wide identification of ubiquitylation sites by conjugation of engineered lysine-less ubiquitin.
 Oshikawa K, Matsumoto M, Oyamada K, Nakayama KI.
 J Proteome Res. 2012 Feb 3;11(2):796-807. [PMID: 22053931]
 [4] hCKSAAP_UbSite: improved prediction of human ubiquitination sites by exploiting amino acid pattern and properties.
 Chen Z, Zhou Y, Song J, Zhang Z.
 Biochim Biophys Acta. 2013 Aug;1834(8):1461-7. [PMID: 23603789]
 [5] Regulation of cellular metabolism by protein lysine acetylation.
 Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL.
 Science. 2010 Feb 19;327(5968):1000-4. [PMID: 20167786] 

Functional Description

 Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water. 

Sequence Annotation

 MOD_RES 295 295 Omega-N-methylated arginine (By  

Keyword

 Aromatic hydrocarbons catabolism; Complete proteome; Detoxification; Direct protein sequencing; Endoplasmic reticulum; Hydrolase; Membrane; Methylation; Microsome; Polymorphism; Reference proteome; Signal-anchor; Transmembrane; Transmembrane helix. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 455 AA 

Protein Sequence

Gene Ontology

 GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0033961; F:cis-stilbene-oxide hydrolase activity; IEA:EC.
 GO:0004301; F:epoxide hydrolase activity; TAS:ProtInc.
 GO:0019439; P:aromatic compound catabolic process; IEA:UniProtKB-KW.
 GO:0014070; P:response to organic cyclic compound; IEA:Compara.
 GO:0009636; P:response to toxic substance; IEA:UniProtKB-KW. 

Interpro

 IPR000073; AB_hydrolase_1.
 IPR000639; Epox_hydrolase-like.
 IPR010497; Epoxide_hydro_N.
 IPR016292; Epoxide_hydrolase. 

Pfam

 PF00561; Abhydrolase_1
 PF06441; EHN 

SMART

  

PROSITE

  

PRINTS

 PR00412; EPOXHYDRLASE.