CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-000817
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
Protein Name
 Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit 
Protein Synonyms/Alias
 DDOST 48 kDa subunit; Oligosaccharyl transferase 48 kDa subunit 
Gene Name
 Ddost 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
174KAPTIVGKSSLNPILacetylation[1]
174KAPTIVGKSSLNPILsuccinylation[1]
174KAPTIVGKSSLNPILubiquitination[2]
286ALSRWVFKEEGVLRVacetylation[1]
Reference
 [1] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [2] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues.
 Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C.
 Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [PMID: 22790023] 
Functional Description
 Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. 
Sequence Annotation
  
Keyword
 Complete proteome; Direct protein sequencing; Endoplasmic reticulum; Glycosyltransferase; Membrane; Reference proteome; Signal; Transferase; Transmembrane; Transmembrane helix. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 441 AA 
Protein Sequence
MKMDPRLAVR AWPLCGLLLA VLGCVCASGP RTLVLLDNLN VRDTHSLFFR SLKDRGFELT 60
FKTADDPSLS LIKYGEFLYD NLIIFSPSVE DFGGNINVET ISAFIDGGGS VLVAASSDIG 120
DPLRELGSEC GIEFDEEKTA VIDHHNYDVS DLGQHTLIVA DTENLLKAPT IVGKSSLNPI 180
LFRGVGMVAD PDNPLVLDIL TGSSTSYSFF PDKPITQYPH AVGRNTLLIA GLQARNNARV 240
IFSGSLDFFS DAFFNSAVQK ATPGAQRYSQ TGNYELAVAL SRWVFKEEGV LRVGPVSHHR 300
VGEMAPPNAY TVTDLVEYSI IIEQLSNGKW VPFDGDDIQL EFVRIDPFVR TFLKRKGGKY 360
SVQFKLPDVY GVFQFKVDYN RLGYTHLYSS TQVSVRPLQH TQYERFIPSA YPYYASAFSM 420
MAGLFIFSIV FLHMKEKEKS D 441 
Gene Ontology
 GO:0016021; C:integral to membrane; IEA:UniProtKB-KW.
 GO:0008250; C:oligosaccharyltransferase complex; ISS:UniProtKB.
 GO:0004579; F:dolichyl-diphosphooligosaccharide-protein glycotransferase activity; IEA:InterPro.
 GO:0006486; P:protein glycosylation; ISS:UniProtKB.
 GO:0018279; P:protein N-linked glycosylation via asparagine; IEA:InterPro.
 GO:0034097; P:response to cytokine stimulus; IEA:Compara.
 GO:0042110; P:T cell activation; IEA:Compara. 
Interpro
 IPR005013; WBP1. 
Pfam
 PF03345; DDOST_48kD 
SMART
  
PROSITE
  
PRINTS