UniProt Accession

 IGHE_HUMAN; P01854 

Genbank Protein ID

 L00022; J00222; AL928742 

Genbank Nucleotide ID

 AAB59424.1; AAB59395.1 

Protein Name

 Ig epsilon chain C region 

Protein Synonyms/Alias

  

Gene Name

 IGHE 

Gene Synonyms/Alias

  

Created Date

 July 27, 2013 

Organism

 Homo sapiens (Human) 

NCBI Taxa ID

 9606 

Lysine Modification

Position	Peptide	Type	References
100	STDWVDNKTFSVCSR	ubiquitination	[1]
207	HTFEDSTKKCADSNP	ubiquitination	[1]
208	TFEDSTKKCADSNPR	ubiquitination	[1]
233	PFDLFIRKSPTITCL	ubiquitination	[1]
261	TWSRASGKPVNHSTR	ubiquitination	[1]
316	ALMRSTTKTSGPRAA	ubiquitination	[1]
400	TRAEWEQKDEFICRA	ubiquitination	[1]

Reference

 [1] Systematic and quantitative assessment of the ubiquitin-modified proteome.
 Kim W, Bennett EJ, Huttlin EL, Guo A, Li J, Possemato A, Sowa ME, Rad R, Rush J, Comb MJ, Harper JW, Gygi SP.
 Mol Cell. 2011 Oct 21;44(2):325-40. [PMID: 21906983] 

Functional Description

  

Sequence Annotation

 DOMAIN 6 103 Ig-like 1.
 DOMAIN 112 210 Ig-like 2.
 DOMAIN 214 318 Ig-like 3.
 DOMAIN 324 423 Ig-like 4.
 CARBOHYD 21 21 N-linked (GlcNAc...).
 CARBOHYD 49 49 N-linked (GlcNAc...).
 CARBOHYD 99 99 N-linked (GlcNAc...).
 CARBOHYD 146 146 N-linked (GlcNAc...).
 CARBOHYD 252 252 N-linked (GlcNAc...).
 CARBOHYD 275 275 N-linked (GlcNAc...).
 DISULFID 14 14 Interchain (with a light chain).
 DISULFID 15 105
 DISULFID 29 85
 DISULFID 121 121 Interchain (with a heavy chain).
 DISULFID 135 193
 DISULFID 209 209 Interchain (with a heavy chain).
 DISULFID 239 299
 DISULFID 345 405  

Keyword

 3D-structure; Complete proteome; Direct protein sequencing; Disulfide bond; Glycoprotein; Immunoglobulin C region; Immunoglobulin domain; Polymorphism; Reference proteome; Repeat. 

Sequence Source

 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 

Protein Length

 428 AA 

Protein Sequence

Gene Ontology

 GO:0003823; F:antigen binding; NAS:UniProtKB.
 GO:0006955; P:immune response; NAS:UniProtKB. 

Interpro

 IPR007110; Ig-like_dom.
 IPR013783; Ig-like_fold.
 IPR003006; Ig/MHC_CS.
 IPR003597; Ig_C1-set. 

Pfam

 PF07654; C1-set 

SMART

 SM00407; IGc1 

PROSITE

 PS50835; IG_LIKE
 PS00290; IG_MHC 

PRINTS