CPLM 1.0 - Compendium of Protein Lysine Modification
TagContent
CPLM ID CPLM-038512
UniProt Accession
Genbank Protein ID
Genbank Nucleotide ID
  
Protein Name
 Methylglutaconyl-CoA hydratase, mitochondrial 
Protein Synonyms/Alias
  
Gene Name
 Auh 
Gene Synonyms/Alias
  
Created Date
 July 27, 2013 
Organism
 Mus musculus (Mouse) 
NCBI Taxa ID
 10090 
Lysine Modification
Position
Peptide
Type
References
47RGYSSEVKTEDELRVacetylation[1]
75GINRAYGKNALSKNLacetylation[1, 2, 3]
75GINRAYGKNALSKNLsuccinylation[2]
84ALSKNLLKMLSKAVDacetylation[1, 2, 3]
84ALSKNLLKMLSKAVDsuccinylation[2]
88NLLKMLSKAVDALKSacetylation[1, 2, 3, 4]
88NLLKMLSKAVDALKSsuccinylation[2]
Reference
 [1] Label-free quantitative proteomics of the lysine acetylome in mitochondria identifies substrates of SIRT3 in metabolic pathways.
 Rardin MJ, Newman JC, Held JM, Cusack MP, Sorensen DJ, Li B, Schilling B, Mooney SD, Kahn CR, Verdin E, Gibson BW.
 Proc Natl Acad Sci U S A. 2013 Apr 16;110(16):6601-6. [PMID: 23576753]
 [2] SIRT5-Mediated Lysine Desuccinylation Impacts Diverse Metabolic Pathways.
 Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y.
 Mol Cell. 2013 Jun 27;50(6):919-30. [PMID: 23806337]
 [3] Quantification of mitochondrial acetylation dynamics highlights prominent sites of metabolic regulation.
 Still AJ, Floyd BJ, Hebert AS, Bingman CA, Carson JJ, Gunderson DR, Dolan BK, Grimsrud PA, Dittenhafer-Reed KE, Stapleton DS, Keller MP, Westphall MS, Denu JM, Attie AD, Coon JJ, Pagliarini DJ.
 J Biol Chem. 2013 Jul 17;. [PMID: 23864654]
 [4] The fasted/fed mouse metabolic acetylome: N6-acetylation differences suggest acetylation coordinates organ-specific fuel switching.
 Yang L, Vaitheesvaran B, Hartil K, Robinson AJ, Hoopmann MR, Eng JK, Kurland IJ, Bruce JE.
 J Proteome Res. 2011 Sep 2;10(9):4134-49. [PMID: 21728379
Functional Description
  
Sequence Annotation
  
Keyword
 Complete proteome; Reference proteome. 
Sequence Source
 UniProt (SWISSPROT/TrEMBL); GenBank; EMBL 
Protein Length
 115 AA 
Protein Sequence
MAAAAPGALG ALRTVGVRLV AACCARLGPA AWARGTAPRR GYSSEVKTED ELRVRHLEEE 60
NRGIVVLGIN RAYGKNALSK NLLKMLSKAV DALKSDKKVR TIIIRSEVPG IFCAE 115 
Gene Ontology
 GO:0005739; C:mitochondrion; IDA:MGI.
 GO:0004300; F:enoyl-CoA hydratase activity; IDA:MGI.
 GO:0003723; F:RNA binding; IDA:MGI.
 GO:0000288; P:nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; TAS:MGI. 
Interpro
 IPR001753; Crotonase_core_superfam. 
Pfam
 PF00378; ECH 
SMART
  
PROSITE
  
PRINTS