Tag | Content |
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CPLM ID | CPLM-008275 |
UniProt Accession | |
Genbank Protein ID | |
Genbank Nucleotide ID | |
Protein Name | Arylamine N-acetyltransferase 2 |
Protein Synonyms/Alias | Arylamide acetylase 2; N-acetyltransferase type 2; NAT-2 |
Gene Name | Nat2 |
Gene Synonyms/Alias | Aac2 |
Created Date | July 27, 2013 |
Organism | Mus musculus (Mouse) |
NCBI Taxa ID | 10090 |
Lysine Modification | Position | Peptide | Type | References |
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247 | TYRRFSYKDNVDLVE | ubiquitination | [1] |
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Reference | [1] Proteomic analyses reveal divergent ubiquitylation site patterns in murine tissues. Wagner SA, Beli P, Weinert BT, Schölz C, Kelstrup CD, Young C, Nielsen ML, Olsen JV, Brakebusch C, Choudhary C. Mol Cell Proteomics. 2012 Dec;11(12):1578-85. [ PMID: 22790023] |
Functional Description | Participates in the detoxification of a plethora of hydrazine and arylamine drugs. 2-aminofluorene and p-aminobenzoic acid (PABA) are preferred substrates for NAT-2. Less activity with anisidine and barely detectable with SMZ. |
Sequence Annotation | REGION 106 107 Substrate binding (By similarity). ACT_SITE 68 68 Acyl-thioester intermediate (By ACT_SITE 107 107 By similarity. ACT_SITE 122 122 By similarity. BINDING 103 103 Coenzyme A (By similarity). BINDING 104 104 Coenzyme A; via amide nitrogen (By BINDING 208 208 Coenzyme A (By similarity). MOD_RES 246 246 Phosphotyrosine. |
Keyword | Acyltransferase; Complete proteome; Cytoplasm; Phosphoprotein; Polymorphism; Reference proteome; Transferase. |
Sequence Source | UniProt (SWISSPROT/TrEMBL); GenBank; EMBL |
Protein Length | 290 AA |
Protein Sequence | MDIEAYFERI GYQSTRSKLD LKTLTEILQH QIRAIPFENL NIHCGESMEL SLEAIFDQIV 60 RKKRGGWCLQ VNHLLYWALT KLGFETTMLG GYVFNTPANK YSSGMIHLLV QVTISGKDYI 120 VDAGFGRSYQ MWEPLELTSG KDQPQVPAIF RLTEENGTWY LDQIRREQYV PNQEFINSDL 180 LEKNKYRKIY SFTLEPRTIE DFESMNTYLQ TSPASVFTSK SFCSLQTPEG VHCLVGSTLT 240 YRRFSYKDNV DLVEFKSLTE EEIEDVLRTI FGVSLERKLV PKHGDRFFTI 290 |
Gene Ontology | GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell. GO:0004060; F:arylamine N-acetyltransferase activity; IDA:MGI. |
Interpro | |
Pfam | |
SMART | |
PROSITE | |
PRINTS | |